Results 71 to 80 of about 1,217,820 (328)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Сoncentrated force acting near the tip of an interface crack with a rigid overlay on its side

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
Plane stress state near the tip of an interface crack induced by specified concentrated force is considered. One of the crack faces is partially reinforced by a rigid straight line overlay.
Yulia O Vasilyeva, Vasiliy V Silvestrov
doaj  

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source

Crack path selection at the interface of wrought and wire+arc additive manufactured Ti–6Al–4V [PDF]

, 2016
Crack propagation deviation tendency in specimens containing an interface between wrought alloy substrate and Wire + Arc Additive Manufacture (WAAM) built Ti–6Al–4V is investigated from the viewpoints of microstructure, residual stress and bi-material ...
Addison, Antonysamy, Antonysamy, ASTM, Baufeld, Baufeld, Brandl, Brandl, Colegrove, Dahlin, Dattoma, Ding, Edwards, Edwards, Edwards, Evans, Fan, Frazier, Hills, Irwin, Kelly, Leuders, Lorant, Martina, Mok, Nègre, Paradowska, Peters, Pippan, Prime, Prime, Rangaswamy, Schroeder, Taminger, Van Hooreweder, Wang, Wang, Zhang, Zhang, Zhu   +39 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Specific complex of non-radiation risk factors for socially significant pathologies could affect the liquidators of Chernobyl nuclear power plant accident [PDF]

Саратовский научно-медицинский журнал, 2014
The review considers the complex of non-radiation factors that could affect the liquidators of the Chernobyl accident: the demographic, social and professional group heterogeneity to warrant differentiation of risk, the effects of heavy metals, 'hot ...
Koterov A.N., Ushenkova L.N., Biryukov А.Р.   +2 more
doaj  

Aspects of fracture mechanics in cryogenic model design. Part 1: Fundamentals of fracture mechanics [PDF]

, 1983
The use of fracture mechanics for predicting fracture and fatigue crack growth in metals is ...
Hudson, C. M.
core   +1 more source

A novel weight function for RMS stress intensity factor determination in surface cracks [PDF]

, 2010
This paper discusses the problem of stress intensity factor determination in surface cracks. In particular, the concept of root mean square stress intensity factors (RMS SIF) is discussed for the general class of semi-elliptical surface cracks.
Brennan, Feargal P., Chahardehi, Amir Ebrahim   +1 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source