Results 61 to 70 of about 945,932 (306)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Research on the Design Concept and Practice of Corporate Compliance Governance Systems [PDF]
SHS Web of ConferencesConsidering the current global economic integration and the rapid development of the market economy, corporate compliance and governance involve compliance with legal regulations and many comprehensive issues, both internal and external.
Tian Zhen
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Scientific Substantiation of the Hotel Business Compliance in Pandemic Conditions
Ресторанний і готельний консалтинг: Інновації, 2020 The topicality. The conditions of the pandemic lockdown prompted economic entities to restructure their activities in accordance with the new communication and operational rules.
Liudmіla Bovsh +2 more
doaj +1 more source
Governance and information governance: some ethical considerations within an expanding information society [PDF]
, 2007 Governance and information governance ought to be an integral part of any government or organisations information and business strategy. More than ever before information and knowledge can be produced, exchanged, shared and communicated through many ...
Atherton, Andrew +2 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
BMC Health Services Research, 2010 Background The functional referral system is important in backing-up antenatal, labour and delivery, and postnatal services in the primary level of care facilities.
Lindmark Gunilla +5 more
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Jurnal Tata Kelola dan Akuntabilitas Keuangan NegaraIndonesian ministries face challenges in maintaining a strong internal control system, as demonstrated by BPK Audit findings that identified significant internal control weaknesses that led to substantial non-compliance incidents across ministries. This
Aditya Pratama, Susanto Salim
doaj +1 more source
Food safety standards: GMP and SSOP in rendang production by MSMEs in Padang [PDF]
E3S Web of ConferencesFood MSMEs play a crucial role in the food industry, contributing to economic growth and food security. In Padang City, food safety concerns, including food poisoning cases, underscore the need for proper food safety practices among business owners.
Fithri Prima +4 more
doaj +1 more source