Results 71 to 80 of about 945,932 (306)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The Role of the Audit Committee In Risk Management [PDF]
, 2007 Risk is a Board responsibility, which cannot be delegated. The boundaries of the audit committee lie somewhere below strategic risk, which is a Board function, and above detailed internal control, which belongs to management.
Bender, Ruth
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Financial Stability Board: Mandate and Implementation of Its Systemic Risks Standards
International Journal of Financial Studies, 2014 The aim of this essay is to provide an overview of the Financial Stability Board’s (FSB) mandate and tools to safeguard financial stability and reduce systemic risks based on the methodological perspective of a legal analysis.
Rolf H. Weber, Dominic N. Staiger
doaj +1 more source
Financial Risks of Investments in Coal [PDF]
, 2011 Analyzes the regulatory, commodity, and construction risks of investing in coal mining and coal-fired power plants. Examines industry analysts' consensus on viable alternatives to coal, including natural gas, solar, wind, and energy ...
Amy Galland, Leslie Lowe, Tom Sanzillo
core
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Are OSHA Health Inspections Effective? A Longitudinal Study in the Manufacturing Sector [PDF]
We examine the impact of OSHA health inspections on compliance with agency regulations in the manufacturing sector, with a unique plant-level dataset of inspection and compliance behavior during 1972-1983, the first twelve years of OSHA enforcement ...
Carol Adaire Jones, Wayne B. Gray
core
Ethical and compliance-competence evaluation: a key element of sound corporate governance [PDF]
, 2007 Motivated by the ongoing post-Enron refocusing on corporate governance and the shift by the Financial Services Authority (FSA) in the UK to promoting compliance- competence within the financial services sector, this paper demonstrates how template ...
Edwards, Jonathan M., Wolfe, S.
core +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Motivating compliance behaviors in public health through enhanced sense of control
Journal of Pacific Rim PsychologyCompliance with medical interventions is crucial for the effectiveness of treatment strategies in public health. Approaches to encourage compliance with health interventions vary in both form and methodology.
Chan Li +3 more
doaj +1 more source