Results 51 to 60 of about 3,293,835 (293)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Compliant Translational Double Exact Dwell Mechanism

, 2021
A novel compliant translational double exact dwell mechanism incorporating the buckling motion of an initially straight flexible member as its members is introduced. This partially compliant five bar mechanism consists of two rigid links as the crank and

core   +2 more sources

Control with a Compliant Force-Torque Sensor [PDF]

, 2012
There are assembly tasks which require a compliant device at the end-effector since possible disturbances are beyond the bandwidth of robot control. This paper discusses a compliant force-torque sensor for assembly.
Hirzinger, Gerd, Suppa, Michael, Lange, Friedrich   +2 more
core  

Optimization of a Forward-Swept Compliant Mechanism

, 2017
A coupled 3 degree-of-freedom contact-aided compliant mechanism called the Forward Swept Compliant Mechanism (FSCM) is designed optimized for coupling orthogonal translational motion.
James E. Hubbard, Joseph Calogero, Zohaib Hasnain, Mary Frecker   +3 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Design of a crab-like bistable mechanism for nearly equal switching forces in forward and backward directions

, 2018
A compliant bistable mechanism with a crab-like structure for nearly equal switching forces in the forward and backward directions is developed. It consists of four crab-leg-like beams and a shuttle mass.
Dung-An Wang, 王東安, Ngoc Dang Khoa Tran   +2 more
core   +1 more source

Design of the compound compliant Scott-Russel mechanism with non-conventional optimization of flexure hinges [PDF]

, 2023
Compliant mechanisms gain some or all their mobility from the relative flexibility of their joints rather than from rigid-body joints only. Compliant mechanisms can provide many benefits in the solution of design problems: they have less wear, weight ...
Stojiljković, Dušan, Pavlović, Nenad T.   +1 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Configuration Design for the Spatial 3-DOF Translation Fully Compliant Parallel Mechanism

Jixie chuandong, 2018
The compliant hinge of fully compliant parallel mechanism has the defects of creep deformation,backhaul reaction and stress relaxation,two different configurations of fully compliant parallel mechanism are designed based on the spatial parallel mechanism
Li Kunquan, Wen Rui
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