The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo +56 more
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Brain magnetic resonance imaging in imported malaria
Malaria Journal, 2019 Background Previous studies have documented a spectrum of brain magnetic resonance imaging (MRI) abnormalities in patients with cerebral malaria, but little is known about the prevalence of such abnormalities in patients with non-cerebral malaria.
Andreas M. Frölich +8 more
doaj +1 more source
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]
, 2008 Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar +10 more
core +1 more source
Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana
Advances in Hematology, 2016 The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P.
Richmond Afoakwah +4 more
doaj +1 more source
Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes
Frontiers in Cell and Developmental Biology, 2020 Sphingosine-1-phosphate (S1P), a bioactive lipid mediator is involved in an array of biological processes and linked to pathological manifestations. Erythrocyte is known as the major reservoir for S1P as they lack S1P-degrading enzymes (S1P lyase and S1P
Raj Kumar Sah +8 more
doaj +1 more source
The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]
, 2013 Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Constenla, Dagna +4 more
core +2 more sources
Using Decision Analysis to Improve Malaria Control Policy Making [PDF]
, 2009 Malaria and other vector-borne diseases represent a significant and growing burden in many tropical countries. Successfully addressing these threats will require policies that expand access to and use of existing control methods, such as insecticide ...
Anderson, Richard M. +7 more
core +2 more sources
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA
Mediterranean Journal of Hematology and Infectious Diseases, 2017 Background : We evaluated albumin cobalt binding (ACB) assay as a prognostic marker for severe malaria in a medical college setting . Methods :Consecutive adult patients admitted with both vivax and falciparum malaria were evaluated with ACB assay at ...
Kinjalka Ghosh +3 more
doaj +1 more source
Detecting signatures of balancing selection to identify targets of anti-parasite immunity.
, 2010 Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core +1 more source
Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria
Pharmaceuticals, 2010 This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj +1 more source