Results 51 to 60 of about 5,162,387 (284)
Pattern-driven reuse in architecture-centric evolution for service software [PDF]
, 2012 Service-based architectures implement business processes as technical software services to develop enterprise software. As a consequence of frequent business and technical change cycles, the architect requires a reusecentered approach to systematically ...
Pooyan Jamshidi (5276344) +5 more
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis. [PDF]
PLoS Genetics, 2016 Classical quantitative genetic analyses estimate additive and non-additive genetic and environmental components of variance from phenotypes of related individuals without knowing the identities of quantitative trait loci (QTLs). Many studies have found a
Wen Huang, Trudy F C Mackay
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A Web Services Component Discovery and Deployment Architecture for Simulation Model Reuse [PDF]
, 2006 CSPs are widely used in industry, although have yet to operate across organizational boundaries. Reuse across organizations is restricted by the same semantic issues that restrict the inter-organization use of web services. The current representations of
Lycett, M +4 more
core +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Software Components, Architectures and Reuse.
J. Univers. Comput. Sci., 2008 Software Components, Architectures and ...
Rubira,Cecília Mary F. +1 more
openaire +3 more sources
Toward a search architecture for software components [PDF]
Concurrency and Computation: Practice and Experience, 2005 AbstractThe Grid and its related technologies enable large‐scale sharing of resources of various types. We envision that in the near future applications will be completely built in a bottom‐up fashion using software components deployed on various locations and interconnected to form a workflow graph.
Fabrizio Silvestri +3 more
openaire +3 more sources
A Framework For Dynamic Updating In Component-Based Software Systems. [PDF]
, 2007 This paper presents DPICS framework for composing component-based software system that can be modified at runtime. It is based on message pattern interaction between system’s components, which facilitates adding, removing, or replacing a component while ...
Alhazbi, Saleh, Jantan, Aman
core +1 more source