Results 71 to 80 of about 5,162,387 (284)

Issues in Component-Based Development: Towards Specification with ADLs [PDF]

Journal of Systemics, Cybernetics and Informatics, 2006
Software development has been coupled with time and cost problems through history. This has motivated the search for flexible, trustworthy and time and cost-efficient development. In order to achieve this, software reuse appears fundamental and component-
Rafael González, Miguel Torres
doaj  

Women & The Architectural Review: the Gendered Presentation of Architectural Work

Dearq, 2017
As an essential component of architectural education –the architectural review– requires students of architecture to perform regularly before their professors and peers. Feminist performance theory and the history of the representation of the female body
Iturbe Elisa
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Product Networks, Component Modularity and Sourcing

Journal of Technology Management & Innovation, 2009
This paper develops product representations as component networks that evolve from sharing of interfaces with other components in a product and links them to the external world of sourcing.
Anupam Agrawal
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Brain-consistent architecture for imagination

Frontiers in Systems Neuroscience
BackgroundImagination represents a pivotal capability of human intelligence. To develop human-like artificial intelligence, uncovering the computational architecture pertinent to imaginative capabilities through reverse engineering the brain's ...
Hiroshi Yamakawa, Hiroshi Yamakawa, Ayako Fukawa, Ayako Fukawa, Ikuko Eguchi Yairi, Yutaka Matsuo   +5 more
doaj   +1 more source

A Component-based Product Line for Workflow Management Systems

CLEI Electronic Journal, 2018
This paper presents a component-based product line for workflow management systems. The process followed to design the product line was based on the Catalysis method. Extensions were made to represent variability across the process.
Itana Maria de Souza Gimenes, Fabrício Ricardo Lazilha, Edson Alves de Oliveira Junior, Leonor Barroca   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

PERSPECTIVE ARCHITECTURE AND COMPONENTS OF COMPUTER NETWORKS

International Journal of Computing, 2004
This article is about using perspective architecture and components of computer networks will permit to increase productivity and reliability of the specialized computer networks not at the expense of escalating elements of system.
Yaroslav Nykolaychuk, Nazar Krutskevych, Oleg Zastavniy, Taras Grinchyshyn   +3 more
openaire   +2 more sources