Results 81 to 90 of about 394,134 (317)

Uncovering architectural mismatch in component behavior

Science of Computer Programming, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Compare, D, INVERARDI, PAOLA, Wolf, Al
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Product Networks, Component Modularity and Sourcing

Journal of Technology Management & Innovation, 2009
This paper develops product representations as component networks that evolve from sharing of interfaces with other components in a product and links them to the external world of sourcing.
Anupam Agrawal
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Attribute based component design: Supporting model driven development in CbSE [PDF]

, 2007
In analysing the evolution of Software Engineering, the scale of the components has increased, the requirements for different domains become complex and a variety of different component frameworks and their associated models have emerged.
Kyaw, Phyo
core  

Brain-consistent architecture for imagination

Frontiers in Systems Neuroscience
BackgroundImagination represents a pivotal capability of human intelligence. To develop human-like artificial intelligence, uncovering the computational architecture pertinent to imaginative capabilities through reverse engineering the brain's ...
Hiroshi Yamakawa, Hiroshi Yamakawa, Ayako Fukawa, Ayako Fukawa, Ikuko Eguchi Yairi, Yutaka Matsuo   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Web based system architecture for long pulse remote experimentation

, 2010
Remote experimentation (RE) methods will be essential in next generation fusion devices. Requirements for long pulse RE will be: on-line data visualization, on-line data acquisition processes monitoring and on-line data acquisition systems interactions ...
J. Vega, D. Lastra, E. Barrera, Heras, E. de las, Castro, R., E. de las Heras, Lastra, D., R. Castro, M. Ruiz, Vega, Jesús, Ruiz González, Mariano, Barrera Lopez de Turiso, Eduardo   +11 more
core   +1 more source

A Dependable Architecture for COTS-Based Software Systems using Protective Wrappers [PDF]

, 2004
Commercial off-the-shelf (COTS) software components are built to be used as black boxes that cannot be modified. The specific context in whichthese COTS components are employed is not known to their developers.
Rubira, Cecilia M. F., Cecília Mary F. Rubira, Alexander Romanovsky, Paulo Asterio de C. Guerra, Rogério de Lemos, de Lemos, Rogério, de C. Guerra, P.A., Romanovsky, Alexander   +7 more
core   +1 more source