Results 61 to 70 of about 394,134 (317)

Pattern-based customisable transformations for style-based service architecture evolution [PDF]

, 2010
Service-based architecture have now become commonplace, creating the need to address their systematic maintenance and evolution. We propose a layered patternbased transformation framework to support a stepwise and incremental Service-Oriented ...
Ahmad, Aakash, Aakash Ahmad, Claus Pahl, Claus Pahl (12588787), Pahl, Claus, Aakash Ahmad (5022314)   +5 more
core   +1 more source

Data-driven dependency injection for embedded software, enhancing reusability with C++ [PDF]

International Journal of Electronics and Telecommunications
This article presents an architecture for engineering reusable embedded software using modern C++ principles and a custom–built dependency injection framework. It details the framework’s design, specifically tailored for resource-constrained environments.
Slawomir Niespodziany
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Component-based System Software: A Generic Approach [PDF]

, 2007
Component-based software engineering has recently emerged as a promising solution to the development of system-level software. Unfortunately, current approaches are limited to specific platforms and domains.
Madeira, E., Grace, P., Coulson, G., Ueyama, J., Taiani, F.   +4 more
core  

The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis. [PDF]

PLoS Genetics, 2016
Classical quantitative genetic analyses estimate additive and non-additive genetic and environmental components of variance from phenotypes of related individuals without knowing the identities of quantitative trait loci (QTLs). Many studies have found a
Wen Huang, Trudy F C Mackay
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Designing and Constructing Modifiable Middleware using Component Frameworks [PDF]

, 2007
Because of the increasingly diverse and dynamic environments in which they must operate, modern middleware platforms need to explicitly support 'modifiability'.
Parlavantzas, N., Geoff Coulson, Nikos Parlavantzas, Coulson, G.   +3 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source