Results 91 to 100 of about 2,006,814 (315)

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

Advanced Science
Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart ...
Zhihao Liu, Xiyun Bian, Lan Li, Li Liu, Chao Feng, Ying Wang, Jingyu Ni, Sheng Li, Dading Lu, Yanxia Li, Chuanrui Ma, Tian Yu, Xiaolin Xiao, Na Xue, Yuxiang Wang, Chunyan Zhang, Xiaofang Ma, Xiumei Gao, Xiaohui Fan, Xiaozhi Liu, Guanwei Fan   +20 more
doaj   +1 more source

Process-Based Information Systems Development: Taking Advantage of a Component-Based Infrastructure

Business Systems Research, 2017
Background: Owing to the highly competitive business environment in which contemporary organizations have to operate, a quick and effective way of developing and maintaining information systems is of utmost importance to their success.
Pereira José Luís, e Sá Jorge Oliveira   +1 more
doaj   +1 more source

Development of software for computing forming information using a component based approach

International Journal of Naval Architecture and Ocean Engineering, 2009
In shipbuilding industry, the manufacturing technology has advanced at an unprecedented pace for the last decade. As a result, many automatic systems for cutting, welding, etc. have been developed and employed in the manufacturing process and accordingly
Kwang Hee Ko, Jung Seo Park, Jung Kim, Young Bum Kim, Jong Gye Shin   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Contract-Based Design of Embedded Systems Integrating Nominal Behavior and Safety

Complex Systems Informatics and Modeling Quarterly, 2015
The distributed design process for safety-critical embedded systems has become an increasingly difficult challenge: Electronic Control Units (ECUs) in vehicles, for instance, participate in many vehicle functions, while each vehicle function, in turn, is
Bernhard Kaiser, Raphael Weber, Markus Oertel, Eckard Böde, Behrang Monajemi Nejad, Justyna Zander   +5 more
doaj   +1 more source

Research Article Software Component Selection Based on Quality Criteria Using the Analytic Network Process

, 2014
Component based software development (CBSD) endeavors to deliver cost-effective and quality software systems through the selection and integration of commercially available software components.
Nazir, Shah, Ali, Muhammad, Shahzad, Sara, Amin, Rohul, Cosmas, John, Lazaridis, Pavlos, Anwar, Sajid, Sher Afzal, Khan, Nawaz, Muhammad   +8 more
core  

Design Patterns and Component Framework for Building RTSJ-Based Real-Time Middleware [PDF]

, 2010
The middleware is a software layer located on top of the operating system that uses its facilities, integrates with it, and extends its functionality in order to support the development of effective and reliable distributed systems; however, the ...
Alrahmawy, Mohammed
core  

Behavioral consistency checking for component-based software development using the KobrA approach

, 2022
S.77-90 : Ill., Lit.UML has become the 'quasi' standard modeling language in a wide range of system domains, ranging from e-business to safety critical embedded systems, especially with the current trend in component-based system development. Various UML
Bunse, C., Choi, Y.
core  

A generic component model for building systems software [PDF]

, 2008
Component-based software structuring principles are now commonplace at the application level; but componentization is far less established when it comes to building low-level systems software.
Lee, Kevin, Blair, Gordon, Grace, Paul, Blair, G, Grace, P, Lee, K, Taiani, Francois, Taiani, F, Taiani, F., Joolia, A, Sivaharan, T, Lee, K., Sivaharan, T., Coulson, Geoffrey, Sivaharan, Thirunavukkarasu, Joolia, A., Grace, P., Coulson, G., Blair, G., Ueyama, J., Ueyama, Jo, Ueyama, J, Joolia, Ackbar, Coulson, G   +23 more
core   +1 more source