Results 111 to 120 of about 2,006,814 (315)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Principal component analysis and perturbation theory–based robust damage detection of multifunctional aircraft structure [PDF]

, 2013
A fundamental problem in structural damage detection is to define an efficient feature to calculate a damage index. Furthermore, due to perturbations from various sources, we also need to define a rigorous threshold whose overtaking indicates the ...
HAJRYA, Rafik, MECHBAL, Nazih
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fighting CPS Complexity by Component-Based Software Development of Multi-Mode Systems

Designs, 2018
Growing software complexity is an increasing challenge for the software development of modern cyber-physical systems. A classical strategy for taming this complexity is to partition system behaviors into different operational modes specified at design ...
Hang Yin, Hans Hansson
doaj   +1 more source

A Dual Language Approach Extension to UML for the Development of Time-Critical Component-Based Systems

, 2003
A “dual language” component-based approach to the development of real-time critical applications is proposed. UML provides the constructs for modeling the structure of the system and the behavior of the system's components.
Lavazza, Luigi, MORZENTI, ANGELO CARLO, SANDRO MORASCA, Morzenti, Angelo, LUIGI LAVAZZA, Morasca, Sandro   +5 more
core   +1 more source

Models, reflective mechanisms and family-based systems to support dynamic configuration [PDF]

, 2006
Middleware platforms must satisfy an increasingly broad and variable set of requirements arising from the needs of both applications and underlying systems deployed in dynamically changing environments such as environment monitoring and disaster ...
P. Grace, G. Blair, Grace, P., N. Bencomo, Blair, Gordon S., Bencomo, Nelly   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy

Journal of Nanobiotechnology
In the absence of tumor antigen specificity, direct chemokine administration carries the risk of significant “on-target, off-tumor” toxicities, highlighting the need for small-molecule approaches with reduced immunogenicity.
Feng Zhao, Liming Gong, Ping Wang, Dong Chen, Shijie Cao, Feifei Yang, Manqing Tang, Yuanyuan Meng, Yuming Wang, Lin Miao, Yunfei Li, Wei Huang   +11 more
doaj   +1 more source

Component-Based Software Development [PDF]

, 2004
Component-based software development (CBD) is an emerging discipline that promises to take software engineering into a new era. Building on the achievements of object-oriented software construction, CBD aims to deliver software engineering from a cottage industry into an industrial age for Information Technology, wherein software can be assembled from ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source