Results 41 to 50 of about 233,547 (264)

Component Mode Synthesis Using Undeformed Interface Coupling Modes to Connect Soft and Stiff Substructures

open access: yesShock and Vibration, 2013
Classical component mode synthesis methods for reduction are usually limited by the size and compatibility of the coupling interfaces. A component mode synthesis approach with constrained coupling interfaces is presented for vibro-acoustic modelling. The
Eskil Lindberg   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Dynamic Modeling of the Multiring Disk Resonator Gyroscope

open access: yesMicromachines, 2019
The multiring disk resonator gyroscope (DRG) has been a candidate for high performance gyroscopes, however nowadays the finite element method (FEM) is the main method for its analysis due to its complex structure. In this paper we propose a new method to
Qingsong Li   +6 more
doaj   +1 more source

Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days

open access: yesDevelopmental Cognitive Neuroscience, 2023
Brain iron is vital for core neurodevelopmental processes including myelination and neurotransmitter synthesis and, accordingly, iron accumulates in the brain with age.
Lanxin Ji   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Stabilized Solution to Spurious Mode Problem and Ill-Conditioning in Interface Force Based Substructure Coupling Method

open access: yesShock and Vibration, 2018
There are two major types of substructure mode synthesis methods, i.e., the fixed-interface component mode synthesis and free-interface component mode synthesis.
Hui-hua Feng   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparison Component Mode Synthesis Method with MSC-NASTRAN

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1983
The authors proposed a component mod synthesis method (CMS in brief) and a multiple component mode synthesis method (MCMS in brief) in the former papers on their study for analyzing the vibration of complex mechanical structures. In the present report, CPU time and accuracy of calculation by CMS and MCMS are compared with those with MSC-NASTRAN ...
OOKUMA, Masaaki, NAGAMATSU, Akio
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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