Results 61 to 70 of about 233,547 (264)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Interval and fuzzy eigenfrequency analysis of uncertain substructured FE models
Computer Assisted Methods in Engineering and Science, 2022 This paper uses an interval and fuzzy finite element approach for the eigenfrequency analysis of a mechanical structure with uncertain parameters. The component mode synthesis method is applied for the numerical reduction of the structure, in order to ...
Hilde De Gersem +3 more
doaj
A hybrid method of component mode synthesis
Computers & Structures, 1971 A method is described for representing a structural component by means of its vibration modes. The modes used to describe the component may have the connection points to the remainder of the structure free, or fixed, or some points free and some points fixed. The modes may either be calculated or experimentally measured.
openaire +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Application of System-level Analysis Method in Fan-driven Gearbox Test
Jixie chuandong, 2021 The fan-driven gearbox is characterized by complex structure and difficult system dynamics analysis. The accuracy of the component level model is verified through the modal analysis and the percussion modal test of the gearbox component.
Lü Zuopeng +4 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Scientific ReportsTo mitigate mode collapse in Deep Convolutional Generative Adversarial Networks (DCGANs), this study proposes an innovative deep learning model integrating Principal Component Analysis (PCA)—the PCA-enhanced Deep Convolutional Generative Adversarial ...
Zhiwei Gao +5 more
doaj +1 more source
Nonlinear Normal Modes of a Rotating Shaft Based on the Invariant Manifold Method
International Journal of Rotating Machinery, 2004 The nonlinear normal mode methodology is generalized to the study of a rotating shaft supported by two short journal bearings. For rotating shafts, nonlinearities are generated by forces arising from the supporting hydraulic bearings.
Mathias Legrand +3 more
doaj +1 more source