Results 61 to 70 of about 7,639,113 (289)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Low cost metamodel for robust design of periodic nonlinear coupled micro-systems

MATEC Web of Conferences, 2016
To achieve robust design, in presence of uncertainty, nonlinearity and structural periodicity, a metamodel combining the Latin Hypercube Sampling (LHS) method for uncertainty propagation and an enriched Craig-Bampton Component Mode Synthesis approach (CB-
Chikhaoui K., Bouhaddi N., Kacem N., Guedri M., Soula M.   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Nonlinear vibrations of large structures with uncertain parameters

Advances in Mechanical Engineering, 2017
The effects of uncertainties on the nonlinear dynamics of complex structures remain poorly mastered and most methods deal with the linear case. This article deals with a model of a large and complex structure with uncertain parameters for the nonlinear ...
Mohammed Lamrhari, Driss Sarsri, Lahcen Azrar, Miloud Rahmoune, Khalid Sbai   +4 more
doaj   +1 more source

Wavelets for intonation modeling in HMM speech synthesis [PDF]

, 2013
The pitch contour in speech contains information about different linguistic units at several distinct temporal scales. At the finest level, the microprosodic cues are purely segmental in nature, whereas in the coarser time scales, lexical tones, word ...
Suni, Antti Santeri, Alku, Paavo, Vainio, Martti, Suni, Antti, Aalto, Daniel, Raitio, Tuomo   +5 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Model of the Dynamic Error as a Measurement Result of Instruments Defining the Parameters of Moving Objects

Measurement Science Review, 2014
The present paper considers a new model for the formation of the dynamic error inertial component. It is very effective in the analysis and synthesis of measuring instruments positioned on moving objects and measuring their movement parameters. The block
Dichev D., Koev H., Bakalova T., Louda P.   +3 more
doaj   +1 more source

Towards mode switch handling in component-based multi-mode systems

, 2012
Component-based software engineering (CBSE) is becoming a prominent solution to the development of complex embedded systems. Meanwhile, partitioning system behavior into different modes is an effective approach to reduce system complexity.
Hang Yin, Hansson, Hans,, Yin, Hang,, Carlson, Jan,, Hans Hansson, Jan Carlson   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source