Results 71 to 80 of about 1,301,914 (340)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
A reduced interface component mode synthesis method using coarse meshes
, 2017 Component mode synthesis is a technique to simplify the analysis of complicated finite element models. A structure is split into substructures from which reduced order models can be generated and subsequently assembled. A model reduction performance gain
M. Gibanica, T. Abrahamsson, D. Rixen
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Low cost metamodel for robust design of periodic nonlinear coupled micro-systems
MATEC Web of Conferences, 2016 To achieve robust design, in presence of uncertainty, nonlinearity and structural periodicity, a metamodel combining the Latin Hypercube Sampling (LHS) method for uncertainty propagation and an enriched Craig-Bampton Component Mode Synthesis approach (CB-
Chikhaoui K. +4 more
doaj +1 more source
Identification of structural interface characteristics using component mode synthesis [PDF]
The inability to adequately model connections has limited the ability to predict overall system dynamic response. Connections between structural components are often mechanically complex and difficult to accurately model analytically. Improved analytical
Huckelbridge, A. A., Lawrence, C.
core +1 more source
GENUS : a generic component library for high level synthesis [PDF]
, 1988 This report describes the organization of GENUS, a generic component library for high level synthesis. Generic components and instances in GENUS are organized into hierarchical classes, with the component type stored at the root of the hierarchy, and ...
Dutt, Nikil D.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Accuracy of results with NASTRAN modal synthesis [PDF]
A new method for component mode synthesis was developed for installation in NASTRAN level 17.5. Results obtained from the new method are presented, and these results are compared with existing modal synthesis ...
Herting, D. N.
core +1 more source
Hiding variables when decomposing specifications into GR(1) contracts [PDF]
, 2017 We propose a method for eliminating variables from component specifications during the decomposition of GR(1) properties into contracts. The variables that can be eliminated are identified by parameterizing the communication architecture to investigate ...
Filippidis, Ioannis, Murray, Richard M.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source