Results 71 to 80 of about 233,547 (264)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Deviatoric component modes in an interval component mode synthesis procedure
, 2008 This paper focuses on the integration of interval uncertainties in the procedure of the Component Mode Synthesis (CMS) method used for the dynamic analysis of large finite element (FE) models in mechanical engineering. Two methods are combined in this work: the Interval Finite Element Method for the nondeterministic eigenvalue and frequency response ...
De Gersem, Hilde +3 more
openaire +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
High-speed tracked vehicle model order reduction for static and dynamic simulations
Defence TechnologyIn this paper, a model order reduction strategy is adopted for the static and dynamic behaviour simulation of a high-speed tracked vehicle. The total number of degree of freedom of the structure is condensed through a selection of interface degrees of ...
Luca Dimauro +4 more
doaj +1 more source
Parametric optimization with the use of numerically efficient finite element models
Advances in Mechanical Engineering, 2015 This article presents numerically efficient computational models for solving exemplary problems of parametric optimization with the use of the finite element method.
Piotr Danielczyk
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Open Engineering, 2017 The application of different mode-shape expansion (MSE) methods to a CFRP based on model order reduction (MOR) and component mode synthesis (CMS) methods is evaluated combining the updated stiffness parameters of the full FE model obtained with a mix ...
Fuentes Humberto Peredo
doaj +1 more source
A Novel Image Fusion Framework Based on Sparse Representation and Pulse Coupled Neural Network
IEEE Access, 2019 Image fusion techniques are applied to the synthesis of two or more images captured in the same scene to obtain a high-quality image. However, most of the existing fusion algorithms are aimed at single-mode images.
Li Yin +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source