Results 51 to 60 of about 7,639,113 (289)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Stabilized Solution to Spurious Mode Problem and Ill-Conditioning in Interface Force Based Substructure Coupling Method

Shock and Vibration, 2018
There are two major types of substructure mode synthesis methods, i.e., the fixed-interface component mode synthesis and free-interface component mode synthesis.
Hui-hua Feng, Xiao-long Mou, Khaled Teffah   +2 more
doaj   +1 more source

Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days

Developmental Cognitive Neuroscience, 2023
Brain iron is vital for core neurodevelopmental processes including myelination and neurotransmitter synthesis and, accordingly, iron accumulates in the brain with age.
Lanxin Ji, Youngwoo Bryan Yoon, Cassandra L. Hendrix, Ellyn C. Kennelly, Amyn Majbri, Tanya Bhatia, Alexis Taylor, Moriah E. Thomason   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparison Component Mode Synthesis Method with MSC-NASTRAN

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1983
The authors proposed a component mod synthesis method (CMS in brief) and a multiple component mode synthesis method (MCMS in brief) in the former papers on their study for analyzing the vibration of complex mechanical structures. In the present report, CPU time and accuracy of calculation by CMS and MCMS are compared with those with MSC-NASTRAN ...
OOKUMA, Masaaki, NAGAMATSU, Akio
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Seismic analyses of i-SMR CV supports employing a component mode synthesis technique

Nuclear Engineering and Technology
To ensure the safety of next-generation reactors, innovative design concepts and subsequent extensive engineering analyses are essential. However, recurrent modifications of major structures, systems and components require substantial resources for ...
Jun-Yeop Lee, Dong-Hyeon Choi, Yoon-Suk Chang   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source