Results 101 to 110 of about 94,918 (283)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Exploring the Tribophysics and Tribochemistry of MoS2 by Sliding MoS2/Ti Composite Coating Under Different Humidity

, 2017
The MoS2 coatings were prepared by unbalanced magnetron sputtering system. Ti was used as the dopant to improve its mechanical properties and oxidation resistance.
Zhang, Guangan, Guangan Zhang, Hao Li, Wang, Liping, Wu, Guizhi, Xia Li, Guizhi Wu, Li, Hao, Liping Wang, Li, Xia   +9 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Surface coating of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement

, 2013
Materials Science & Technology 2012 Conference & Exhibition (MS&T'12), Pittsburgh, Pennsylvania US, 27-31 October 2012Biodegradable polymeric nano-composite scaffolds have recently attracted considerable attention in curing bone deficiencies resulting ...
Tsui, Chi Pong, Tang, CY, Tang, Chak Yin, Tsui, CP, Ling Chen, Chen, DZ, Chi Pong Tsui, Chak Tin Tang, Chen, L, Ku, HSL, Chen, Da Zhu, Da Zhu Chen, Ku, Harry Siu Lung, Harry Siu-Lung Ku, Chen, Ling   +14 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Estudo de cobertura comestível com propriedades antifúngicas e atmosfera modificada na manutenção da qualidade de tomate cereja (Lycopersicon esculentum var. Cerasiforme) [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2013.O tomate é uma hortaliça de grande produção e consumo no Brasil.
Fagundes, Cristiane
core  

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Microstructure and wear resistance of spherical ceramic particles reinforced FeCoNiCrMn composite coating fabricated by laser directional energy deposition

Journal of Materials Research and Technology
FeCoNiCrMn coatings have good plasticity and toughness, but it is difficult to meet the increasing wear resistance requirements. To improve the tribological properties of FeCoNiCrMn coating, WC particles were added to the coating.
Zhiyuan Liu, Yongcun Li, Yong Wang
doaj   +1 more source

Facile preparation of soluble poly(2-aminothiazole)-based composite coating for enhanced corrosion protection in 3.5% NaCl solution

, 2018
Conducting polymer-based coating is the prospective alternative in consideration of environmentfriendly coatings for corrosion protection of metallic substrate. Minimally-researched poly(2-aminothiazole) (PAT) with well-dispersion and good processability
Qiu, Shihui, Zhao, Haichao, Wang, Liping
core