Results 91 to 100 of about 105,174 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Blast response and safety evaluation of a composite column for use as key element in structural systems

open access: yes, 2014
This paper presents the blast response, damage mechanism and evaluation of residual load capacity of a concrete–steel composite (CSC) column using dynamic computer simulation techniques.
Jayasooriya, Ruwan   +2 more
core   +1 more source

Deconstructable Flush End Plate Beam-to-Column Composite Joints: Component- Based Modelling [PDF]

open access: yes, 2018
[EN] Within a paradigm of designing building structures for their end-of-life deconstruction, thispaper addresses flush end plate beam-to-column composite joints that may be dis-assembledand reused elsewhere.
Bradford, Mark, Ataei, A., Liu, X.
core   +1 more source

Review on Composite Joints for Cold-Formed Steel Structures

open access: yesE3S Web of Conferences, 2018
Introduction of the lightweight cold-formed steel (CFS) sections to building construction has been well-established these days due to its high structural performance, corrosion resistance, ease of construction and maintenance as well as aesthetic ...
Amsyar Faisal   +3 more
doaj   +1 more source

Hollow-Core FRP–Concrete–Steel Bridge Columns under Torsional Loading

open access: yesFibers, 2017
This paper presents the behavior of hollow-core fiber-reinforced polymer–concrete–steel (HC-FCS) columns under cyclic torsional loading combined with constant axial load.
Sujith Anumolu   +4 more
doaj   +1 more source

Reliability of composite columns and beam - columns in EUROCODE 4

open access: yesInternational Journal for Engineering Modelling, 1994
The reliability of the design methods in EUROCODE 4, Composite Constructions, for composite columns is studied in this paper. The investigation has been performed for both concretefilled tubes and concrete encased profiles. The research compares the available test-results with the design model of EC-4 using the second order reliability method.
Sulyok - Selimbegović, Marta   +1 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Fire performance of steel-concrete composite structures in China : test, analysis and design approach

open access: yes, 2012
This paper summarizes some of the new developments on fire performance of steel-concrete composite structures in China. The topics include: 1) Fire performance of steel-concrete composite members, such as concrete filled steel tube (CFST) columns and ...
Han, Lin-Hai   +2 more
core  

Optimum design of composite steel frames with semi-rigid connections and column bases via genetic algorithm

open access: yes, 2015
A genetic algorithm-based minimum weight design method is presented for steel frames containing composite beams, semi-rigid connections and column bases.
Artar M., Dalo?lu A.T.
core   +1 more source

Home - About - Disclaimer - Privacy