Results 71 to 80 of about 105,174 (312)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
BuildingsTo address the insufficient strength of conventional crushed stone in liquefiable and soft soil foundations, this research aims to fill the research gap regarding the bearing behavior of geosynthetic-encased recycled concrete aggregate column composite ...
Yaru Wang +6 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Fire performance of blind bolted composite beam to column joints
, 2017 Blind bolts can be used to connect steel beams to concrete filled steel tubular (CFST) columns, and the obtained composite joints have relatively high initial stiffness, flexural resistance, and ductility at ambient temperature.
Han, Lin-Hai +4 more
core +1 more source
Three-dimensional analysis of reinforced concrete beam-column structures in fire [PDF]
, 2009 This is the author's accepted manuscript. The final published article is available from the link below. Published version copyright @ 2009 ASCE.In this paper a robust nonlinear finite-element procedure is developed for three-dimensional modeling of ...
Plank, RJ, Huang, Z, Burgess, IW
core +1 more source
Revista IBRACON de Estruturas e MateriaisThe slim floor system has been used mainly due to the structural and constructive advantages of it, such as the capacity to overcome large spans with the low height of the composite floor system.
R. F. F. KOCHEM, S. de NARDIN
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Instability of composite beams in hogging bending [PDF]
This work is concerned with local buckling and lateral distortional buckling, two aspects of instability that govern the design of composite beams in hogging regions.
Chen, Shiming
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source