Results 61 to 70 of about 99,383 (266)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Behaviour of Hybrid Steel and FRP-Reinforced Concrete—ECC Composite Columns under Reversed Cyclic Loading

Sensors, 2018
Fibre-reinforced polymer (FRP) is used widely in concrete structures owing to its noncorrosive, light-weight, nonmagnetic, and high tensile-strength properties.
Fang Yuan, Liping Chen, Mengcheng Chen, Kaicheng Xu   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Hollow-Core FRP–Concrete–Steel Bridge Columns under Torsional Loading

Fibers, 2017
This paper presents the behavior of hollow-core fiber-reinforced polymer–concrete–steel (HC-FCS) columns under cyclic torsional loading combined with constant axial load.
Sujith Anumolu, Omar I. Abdelkarim, Mohanad M. Abdulazeez, Ahmed Gheni, Mohamed A. ElGawady   +4 more
doaj   +1 more source

Strength of Partially Encased Steel-Concrete Composite Column for Modular Building Structures. [PDF]

Materials (Basel), 2022
Park KS, Lee SS, Bae KW, Moon J.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Experimental study on the seismic performance of a cold-formed thin-walled steel-concrete composite column-H steel beam frame. [PDF]

Sci Rep, 2023
Hou H, Chen Z, Wang X.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

CONCRETE-FILLED TUBULAR COLUMN MADE OF VARIOUS TYPES OF MATERIAL

Journal of Civil Engineering
Concrete-filled tubes (CFT) are gaining popularity due to their excellent performance under compression. Various materials have been used to produce CFTs. Their behavior varied significantly due to the properties of the materials.
Jen Hua Ling, Yong Tat Lim, Wen Kam Leong, How Teck Sia   +3 more
doaj   +1 more source