Results 71 to 80 of about 500,682 (302)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Research on the Theoretical Models of FRP-Confined Gangue Aggregate Concrete Partially Filled Steel Tube Columns

Buildings
FRP-confined gangue aggregate concrete partially filled steel tubes (CGCPFTs) can not only effectively enhance the performance of coal gangue concrete, but also fully exploit the elastic-plastic mechanical behavior of the steel tubes.
Jian Wang, Junwu Xia, Chuanzhi Sun, Jinsheng Cheng, Shengbo Zhou, Jibing Deng   +5 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Behaviour of Hybrid Steel and FRP-Reinforced Concrete—ECC Composite Columns under Reversed Cyclic Loading

Sensors, 2018
Fibre-reinforced polymer (FRP) is used widely in concrete structures owing to its noncorrosive, light-weight, nonmagnetic, and high tensile-strength properties.
Fang Yuan, Liping Chen, Mengcheng Chen, Kaicheng Xu   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Hollow-Core FRP–Concrete–Steel Bridge Columns under Torsional Loading

Fibers, 2017
This paper presents the behavior of hollow-core fiber-reinforced polymer–concrete–steel (HC-FCS) columns under cyclic torsional loading combined with constant axial load.
Sujith Anumolu, Omar I. Abdelkarim, Mohanad M. Abdulazeez, Ahmed Gheni, Mohamed A. ElGawady   +4 more
doaj   +1 more source

Concrete - filled steel tube columns - tests compared with Eurocode 4 [PDF]

, 2008
This paper summarises the data from 1819 tests on concrete-filled steel tube columns and compares their failure load with the prediction of Eurocode 4. The full data is given on the website http://web.ukonline.co.uk/asccs2 .
Goode, C. D., Lam, D.
core  

The Evolution and Eddington Ratio Distribution of Compton Thick Active Galactic Nuclei

, 2010
Previous studies of the active galactic nuclei (AGN) contribution to the cosmic X-ray background (CXB) consider only observable parameters such as luminosity and absorbing column.
Ajello, Alexander, Antonucci, Ballantyne, Draper, Fiore, Fiore, Gendreau, González-Martín, Gruber, Gültekin, Hopkins, Kushino, Malizia, Merloni, Netzer, Page, Polletta, Rigby, Small, Terashima, Treister, Treister, Treister, Tueller, Ueda, Vecchi, Yan   +27 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Buckling of Slender Concrete-Filled Steel Tubes with Compliant Interfaces

Latin American Journal of Solids and Structures
This paper presents an exact model for studying the global buckling of concrete-filled steel tubular (CFST) columns with compliant interfaces between the concrete core and steel tube.
Simon Schnabl, Igor Planinc
doaj   +1 more source