Results 51 to 60 of about 919 (217)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mechanical Performance of Prefabricated Monolithic Composite Columns with Reinforced ECC Precast Shell

Buildings
To enhance the mechanical properties of a precast monolithic column, the ECC material was made into a prefabricated shell with reinforced bars. Post-cast concrete was poured into the precast parts to form the reinforced ECC precast monolithic composite ...
Tingting Lu, Bin Wang, Haowei Jin
doaj   +1 more source

Calculation of Axial Compressive Bearing Capacity of Composite Strengthened Circular Timber Column

工程科学与技术, 2021
The composite strengthening method with near surface mounted steel bars and wrapped fiber reinforced polymer strips can improve the bearing capacity and deformation behavior of timber columns effectively, and enhance their working performance greatly. To
Siha A, Changdong ZHOU
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Compressive strength capacity of light gauge steel composite columns

Case Studies in Construction Materials, 2016
The axial compressive strength capacity of concrete-filled light gauge steel composite columns was assessed through an experimental program involving twelve long and fourteen stub columns with width-to-thickness ratio of 125 for the encasing steel ...
W. Leonardo Cortés-Puentes, Dan Palermo, Alaa Abdulridha, Muslim Majeed   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Experimental and Numerical Study on Reinforced Concrete Columns Strengthened with Lightweight Alkali-Activated Slag Concrete and X-Type Encased Steel

Buildings
As a key load-bearing component in building structures, the effective strengthening of reinforced concrete (RC) columns is critical to enhancing their structural reliability and service life.
Jing Zhu, Zijie Wen, Yuankai Li, Xiaomeng Hou, Yiqi Lu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mechanical Analysis of Hpfrcc Precasted Composite Column

Materials
In order to improve the physical and mechanical properties and the ability to perform in practical applications of prefabricated monolithic composite columns, high-performance fiber-reinforced cementitious composites (HPFRCC) material was prefabricated into mold shells to form HPFRCC precast monolithic composite columns.
Tingting Lu, Bin Wang, Haowei Jin, Yuxiang Wen   +3 more
openaire   +2 more sources