Results 111 to 120 of about 288,253 (317)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Formal Foundations for Reasoning about Composition
, 2001 Designing software systems is difficult. Designing systems that are capable of evolving is even more difficult. Often the system evolves in an unforeseen direction. Practice shows that software systems grow in small evolutionary steps. An evolution usually influences the behavior and the structure of the system.
Glandrup, Maurice, Rensink, Arend
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Six families of flexicurity indicators developed at the Hans Boeckler Foundation [PDF]
The paper is an overview of over 30 publications on six models with flexicurity indicators developed at the Hans-Böckler-Foundation for monitoring and analysis of flexicurity.
Tangian, Andranik
core
Impacts of Different Pile Parameters on Stress and Settlement of Composite Foundation
, 2011 The composite foundation fully takes the carrying capacity of pile and soil into account, which decreases the settlement of oil storage tank foundation and differential settlement of oil storage tank bottom apparently. Analyzing the changes of stress and
Shan Shan Sun, Ying Cui, Jun Hai Zhao
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Field Test on Composite Foundation Incorporating Flexible and Rigid Piles
, 2010 This paper presents three static load tests of composite foundation incorporating flexible piles, rigid piles and different cushion materials to clarify the load-displacement behavior of composite foundation.
Zhong Miao Zhang, Qian Qing Zhang
core +1 more source
BuildingsConcrete-cored sand–gravel piles are a kind of composite pile formed by wrapping a concrete-cored pile with a sand–gravel shell, which has the advantages of both a rigid pile and bulk-material pile.
Binhui Ma +4 more
doaj +1 more source