Results 91 to 100 of about 3,916,940 (335)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Free Vibration and Damping of Rotating Composite Shaft with a Constrained Layer Damping

Shock and Vibration, 2016
The free vibration and damping characteristics of rotating shaft with passive constrained layer damping (CLD) are studied. The shaft is made of fiber reinforced composite materials. A composite beam theory taking into account transverse shear deformation
Yongsheng Ren, Yuhuan Zhang
doaj   +1 more source

The phylogenetic effective sample size and jumps

, 2018
The phylogenetic effective sample size is a parameter that has as its goal the quantification of the amount of independent signal in a phylogenetically correlated sample. It was studied for Brownian motion and Ornstein-Uhlenbeck models of trait evolution.
Bartoszek, Krzysztof
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Flexible Strain Sensor Based on Carbon Black/Silver Nanoparticles Composite for Human Motion Detection

Materials, 2018
The demand for flexible and wearable electronic devices with excellent stretchability and sensitivity is increasing, especially for human motion detection.
Weiyi Zhang, Qiang Liu, Peng Chen
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On dispersion relations in smart laminated fiber-reinforced composite membranes considering different piezoelectric coupling effects

Journal of Low Frequency Noise, Vibration and Active Control, 2019
Wave propagation characteristics are determined for smart laminated fiber-reinforced composite cylindrical membrane shells with different piezoelectric coupling effects. Wave motion equations are derived using the membrane shell model.
Hossein Bisheh, Nan Wu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Investigation into the Effect of Near-Fault Ground Motion Duration Parameters on the Nonlinear Seismic Response of Intake Towers

Buildings
Intake towers, essential for hydraulic hub projects, are integral to maintaining safety and efficiency, especially under seismic conditions that are prevalent near fault zones.
Xi Chen, Binpeng Zhou, Xiaoxiao Liu, Junlong Lu   +3 more
doaj   +1 more source

Geometry generation principle and meshing properties of a new gear drive

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
The generation principle of composite cycloid is proposed for the tooth profile of external drive. Firstly, a two-link mechanism is developed as the equivalent mechanism to describe the geometric principle of cycloid by introducing the motion ...
Zhenhua HAN, Wankai SHI, Chang LIU, Lang XU   +3 more
doaj   +1 more source