Results 111 to 120 of about 509,958 (319)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Cost modelling for manufacturing of aerospace composites [PDF]

open access: yes, 2011
The application of composites has been increasing dramatically in aerospace structures recently, for example, composites have contributed over 50 percent of the structure mass of large transport airplanes Boeing 787 and Airbus 350XWB.
Ma, Weitao
core  

Research on formation mechanism of metal foils texture on composites surface

open access: yesScience and Engineering of Composite Materials
This study investigates the formation mechanisms of metal foil textures on composites surface, focusing on the distinct stripes and patterns observed in areas with layer thickness variations, overlaps, stringer bonding, and curved surface.
Tian Siqiang   +4 more
doaj   +1 more source

A Facile Route to the Preparation of Highly Uniform ZnO@TiO2 Core-Shell Nanorod Arrays with Enhanced Photocatalytic Properties

open access: yesJournal of Chemistry, 2017
Design and synthesis of ZnO@TiO2 core-shell nanorod arrays as promising photocatalysts have been widely reported. However, it remains a challenge to develop a low-temperature, low-cost, and environmentally friendly method to prepare ZnO@TiO2 core-shell ...
Yuanyuan Zhao   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The development of sub-micro filler enhanced polymer composites

open access: yes, 2007
Sub-micro silica flakes and graphite reinforced polymer composites have been developed in this research. The sub-micro polymer composites are designed to overcome problems associated with nanocomposite technology.
Li, Y, Li, Yalan
core  

Tannin-based flax fibre reinforced composites for structural applications in vehicles [PDF]

open access: yes, 2012
Innovation is often driven by changes in government policies regulating the industries, especially true in case of the automotive. Except weight savings, the strict EU regulation of 95% recyclable material-made vehicles drives the manufactures and ...
Zhu, J.   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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