Results 101 to 110 of about 38,889 (311)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A new class of composition operators
International Journal of Mathematics and Mathematical Sciences, 1987 A new class of composition operators Pϕ:H2(T)→H2(T), with ϕ:T→D¯ is introduced. Sufficient conditions on ϕ for Pϕ to be bounded and Hilbert-Schmidt are obtained.
S. Pattanayak +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
On spectra of composition operators
, 2015 In this paper we consider composition operators Cφ on the Hilbert Hardy space over the unit disc, induced by analytic selfmaps φ. We use the fact that the operator C∗φCφ is asymptotically Toeplitz to obtain information on the essential spectrum and ...
Valentin Matache, Matache, Valentin
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Numerical Ranges of Normal Weighted Composition Operators on the Fock Space of CN
Journal of Function Spaces, 2018 Numerical ranges of normal weighted composition operators on the Fock space of CN are completely characterized. The main result shows that numerical ranges of such operators are closely related to their composition symbols.
Lili Lang, Liankuo Zhao
doaj +1 more source
Two-term Szegő theorem for generalised anti-Wick operators
, 2015 This thesis concerns operators whose Weyl pseudodifferential operator symbol is the convolution of a function that is smooth and of fixed scale with a function that is discontinuous and dilated by a large asymptotic parameter.
Oldfield, JP
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source