Results 81 to 90 of about 3,123 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Photovoltaic Array Fault Diagnosis Based on Gaussian Kernel Fuzzy C-Means Clustering Algorithm

Sensors, 2019
In the fault diagnosis process of a photovoltaic (PV) array, it is difficult to discriminate single faults and compound faults with similar signatures. Furthermore, the data collected in the actual field experiment also contains strong noise, which leads
Shengyang Liu, Lei Dong, Xiaozhong Liao, Xiaodong Cao, Xiaoxiao Wang   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Multi-domain vibration dataset with various bearing types under compound machine fault scenarios

Data in Brief
In modern complex mechanical systems, machine faults typically occur in multiple components simultaneously, and the domain of collected sensor data changes continuously due to variations in operating conditions.
Seongjae Lee, Taewan Kim, Taehyoun Kim
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Compound Fault Diagnosis of Bearings Using an Improved Spectral Kurtosis by MCDK [PDF]

, 2018
The fast spectrum kurtosis (FSK) algorithm can adaptively identify and select the resonant frequency band and extract the fault feature by the envelope demodulation method.
Longjiang Dou, Shuting Wan, Xiong Zhang
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Isolation and Identification of Compound Faults in Rotating Machinery via Adaptive Deep Filtering Technique

IEEE Access, 2019
Compound defects commonly occur on rotating machinery under fatigue and heavy loads, and their fault signatures are coupled and easily buried in strong unwanted vibrations and background noise.
Chunlin Zhang, Yuling Liu, Fangyi Wan, Binqiang Chen, Jie Liu   +4 more
doaj   +1 more source

An Improved Dual-Kurtogram-Based T2 Control Chart for Condition Monitoring and Compound Fault Diagnosis of Rolling Bearings

, 2021
Condition monitoring and compound fault diagnosis are crucial key points for ensuring the normal operation of rotating machinery. A novel method for condition monitoring and compound fault diagnosis based on the dual-kurtogram algorithm and multivariate ...
Wei Fan, Zhenying Xu, Zhiyuan Jiao
core   +1 more source