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Contextual Compound Screening for Improved Therapeutic Discovery
ChemBioChem, 2013AbstractCellular behaviors are governed by combinations of systemic and microenvironmental factors; together, these regulate cell signaling responses to growth factors. This contextual microenvironmental influence also determines drug sensitivity. Hence using in vitro systems that model contextual cellular behavior is highly beneficial for effective ...
Lasse, Evensen +8 more
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Screening lead compounds for QT interval prolongation
Drug Discovery Today, 2001The late detection of cardiotoxic side effects, such as QT prolongation, induced by compounds of pharmacological interest can dramatically impede drug discovery and development projects, and consequently increase their cost. The launch of new drugs with undetected cardiotoxic side effects could have hazardous consequences and could trigger lethal ...
R, Netzer +3 more
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Screening of Organic Compounds for Spermicidal Activity
Fertility and Sterility, 1959581 organic compounds were studied for their spermicidal activity by a modified Brown and Gamble method. Of 55 compounds that were considered highly effective in aqueous solutions of .5% or less 31 were surfactant substances. A new class of polyhydric phenols bismonohydroxy and bisdihydroxyphenyl derivatives of methane were discovered to have strong ...
J H, HOLZAEPFEL +3 more
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Structure-based screening of low-affinity compounds
Drug Discovery Today, 2002Conventional bioassay-based screening remains a mainstream approach for lead discovery. However, its limitations have meant that other, more biophysical methods, such as X-ray crystallography and NMR, are now being developed as lead discovery tools. These methods are particularly effective at detecting the binding of low affinity, low molecular weight ...
Robin, Carr, Harren, Jhoti
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Virtual Screening of Anti‐Mycobacterial Plant Compounds
Molecular Informatics, 2013AbstractDeaths from tuberculosis have long gripped people and threatened human health. The need for new drug compounds are critically sensed by medical scientists and practitioners due to the emergence of new strains and the slow rate of discovering novel medicines for this disease.
Fatemeh, Saadat +2 more
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Design of compound libraries for fragment screening
Journal of Computer-Aided Molecular Design, 2009Approaches to the design of libraries for fragment screening are illustrated with reference to a 20 k generic fragment screening library and a 1.2 k generic NMR screening library. Tools and methods for library design that have been developed within AstraZeneca are described, including Foyfi fingerprints and the Flush program for neighborhood ...
Niklas, Blomberg +3 more
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Screening for chemopreventive (anticarcinogenic) compounds in rodents
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992The Chemoprevention Branch is testing dozens of candidate chemopreventive compounds in the following rodent model carcinogenesis systems: mouse skin papillomas, DMBA/TPA induced, rat mammary adenocarcinoma, DMBA and MNU induced, hamster tracheal squamous cell carcinoma, MNU induced, and lung adenocarcinoma, DEN induced, rat and mouse colon ...
C W, Boone, V E, Steele, G J, Kelloff
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Screening Microorganisms for Bioactive Compounds
2016Novel bioactive compounds are in high demand due to the development of microbial antibiotic resistance, increase in age-related diseases, and requirements for optimized manufacturing processes. The bioactive compounds can act as specific antitumor, anti-inflammatory, and antifungal compounds as well as pharmaceuticals against metabolic diseases ...
Sonia Giubergia +6 more
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Cheminformatic Analysis of High-Throughput Compound Screens
2013This article gives an overview of basic computational methods that are commonly used for analyzing small molecule screening data in the chemical genomics field. First, we introduce cheminformatic concepts for analyzing drug-like small molecule structures and their properties.
Tyler W H, Backman, Thomas, Girke
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Screening for new compounds with antiherpes activity
Antiviral Research, 1984A number of compounds have been tested for antiherpes activity. Actinobolin, amicetin, carrageenan, laspartomycin, megalomycin C, pleuromutilin, suramin and tetracenomycin C showed significant protection of HeLa cell monolayers infected with herpes simplex virus type 1.
B, Alarcón +3 more
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