Results 251 to 260 of about 359,557 (359)

Zebrafish embryo sensitivity test as in vivo platform to anti-Shiga toxin compound screening. [PDF]

Braz J Microbiol, 2020
de Sousa Melo B, Fernandes BHV, Lopes-Ferreira MVA, Henrique C, Piazza RMF, Luz D.   +5 more
europepmc   +1 more source

Discovery of novel anti-proliferative compounds against A549 cells by virtual screening

, 2010
Pradeesh Babu, Mangamoori L Narasu, Srinivas Kolli   +2 more
openalex   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice. [PDF]

Front Pharmacol
Maeda K, Tanimura M, Masago Y, Horiyama T, Takemoto H, Sasaki T, Koyama R, Ikegaya Y, Ogawa K.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection. [PDF]

Cell Rep Med
Knapp K, Klasinc R, Koren A, Siller M, Dingelmaier-Hovorka R, Drach M, Sanchez J, Chromy D, Kranawetter M, Grimm C, Bergthaler A, Kubicek S, Stockinger H, Stary G.   +13 more
europepmc   +1 more source

Computational and Mutational Hotspot Analysis of Mycobacterial Inorganic Pyrophosphatase and Virtual Screening of Natural Compounds to Discover Potential Therapeutics [PDF]

Shivangi, Laxman S. Meena
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening. [PDF]

ACS Med Chem Lett, 2020
Smit T, Calitz C, Willers C, Svitina H, Hamman J, Fey SJ, Gouws C, Wrzesinski K.   +7 more
europepmc   +1 more source

Target-based Virtual Screening of Natural Compounds as Promising Anti-Parkinson’s Agents

Israa J. Hakeem
openalex   +1 more source