Results 251 to 260 of about 690,492 (301)
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Screening Assay for Promigratory/Antimigratory Compounds
Analytical Biochemistry, 2000Large-scale screening strategies aimed at finding anticancer drugs traditionally focus on identifying cytotoxic compounds that attack actively dividing cells. Because progression to malignancy involves acquisition of an aggressively invasive phenotype in addition to hyperproliferation, simple and effective screening strategies for finding compounds ...
W L, Rust, J L, Huff, G E, Plopper
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The Future of Virtual Compound Screening
Chemical Biology & Drug Design, 2012We provide a future perspective of the virtual screening field. A number of challenges will be highlighted that virtual screening will likely face when compound data will further grow at or beyond current rates and when much more target information will become available.
Kathrin, Heikamp, Jürgen, Bajorath
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Virtual Screening of Compound Libraries
2009During the last decade, Virtual Screening (VS) has definitively established itself as an important part of the drug discovery and development process. VS involves the selection of likely drug candidates from large libraries of chemical structures by using computational methodologies, but the generic definition of VS encompasses many different ...
Nuno M F S A, Cerqueira +3 more
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The evolution of microarrayed compound screening
Drug Discovery Today, 2004This review describes recent developments in the evolutionary process of microarrayed compound screening (microARCS to become a robust and efficient ultra-high-throughput screening technology. Improvements in compound spotting (including new quality-control methods), gel casting and imaging, together with software capable of automatic analysis and ...
Michael, Hoever, Peter, Zbinden
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Substituted tetrazoles as multipurpose screening compounds
Molecular Diversity, 2016Tetrazoles are small functional heterocycles that are suited to serve simultaneously as aromatic platform for diversity and as functional interaction motif. Furthermore, the tetrazole ring and its deprotonated tetrazolate counterpart are metal ion complexing ligands that possess a rich variety of binding and bridging modes.
Nicole Rüger +5 more
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Virtual Compound Screening In Drug Discovery
Future Medicinal Chemistry, 2012Virtual screening (VS) methods are applied in both academia and drug discovery, and can be divided into ligand- and target structure-based approaches. The VS field is still evolving and is characterized by scientific heterogeneity. The value of virtual compound screening for drug discovery is often debated, in particular, given the large investments ...
Dagmar, Stumpfe +2 more
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Deconvolution Approaches in Screening Compound Mixtures
Combinatorial Chemistry & High Throughput Screening, 1997Combinatorial chemistry initiatives can be used to generate compound mixtures, and it has become a challenge to effectively screen these mixtures for activity against a specified target. Overall mixture activity can be readily measured, however it is not c;J. straightforward matter to identify all those components giving rise to the total activity
D C, Schriemer, O, Hindsgaul
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Compound Collection Preparation for Virtual Screening
2012Virtual screening is an established technique that has successfully been deployed in the identification of novel biologically active molecules. Whether for ligand-based or for structure-based virtual screening, a chemical collection needs to be properly processed prior to in silico evaluation.
Cristian G, Bologa, Tudor I, Oprea
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ELECTROSTATIC SCREENING IN FULLERENE COMPOUNDS
Modern Physics Letters B, 1994We study the Coulomb interactions in fullerene compounds within a continuum formalism. The model gives rise to a renormalizable field theory, which has many similarities to standard quantum electrodynamics. The effective electric charge at low energies is reduced by screening processes.
J. GONZÁLEZ +2 more
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Screening for Anti-proteolytic Compounds
2009Dietary protein entering the rumen is broken down in an apparently uncontrolled way, resulting in ammonia formation and subsequent loss of N in the urine. The low efficiency of nitrogen retention represents a major economic loss, causes metabolic stress in the animal, and places a burden on the environment, by way of nitrogen-rich wastes. If a means of
Ellen M. Hoffmann +4 more
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