Results 231 to 240 of about 359,557 (359)

A high throughput strategy for traditional Chinese medicine active compound screening based on Raman spectroscopy. [PDF]

J Pharm Anal
Tian M, Ma X, Li Y, Zang H, Li L.
europepmc   +1 more source

Screening of 67 compounds with predicted biosignature profile similar to remdesivir for anti-SARS-CoV-2 activity

, 2022
Ellen Van Damme
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out. [PDF]

PLoS One
Wilbie D, Eising S, Amo-Addae V, Walther J, Bosman E, Lei Z, de Jong OG, Molenaar JJ, Mastrobattista E.   +8 more
europepmc   +1 more source

Epigenetic Compound Screening Uncovers Small Molecules for Reactivation of Latent HIV-1. [PDF]

Antimicrob Agents Chemother, 2020
Zutz A, Chen L, Sippl F, Humpe A, Schölz C.   +4 more
europepmc   +1 more source

Reduction of chickens use to perform <i>in vitro</i> pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current <i>Eimeria tenella</i> compound-screening model. [PDF]

F1000Res, 2022
Arias-Maroto S, Aguiar-Martins K, Regidor-Cerrillo J, Ortega-Mora L, Marugan-Hernandez V.   +4 more
europepmc   +1 more source

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells [PDF]

, 2016
Bastien Gerby, Diogo F. T. Veiga, Jana Krošl, Sami Nourreddine, Julianne Ouellette, André Haman, Geneviève Lavoie, Iman Fares, Mathieu Tremblay, Véronique Litalien, Elizabeth Ottoni, Milena Kosic, Dominique Geoffrion, Joël Ryan, Paul S. Maddox, Jalila Chagraoui, Anne Marinier, Josée Hébert, Guy Sauvageau, Benjamin H. Kwok, Philippe P. Roux, Trang Hoang   +21 more
openalex   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Unveiling CNS cell morphology with deep learning: A gateway to anti-inflammatory compound screening. [PDF]

PLoS One
Bahng H, Oh JP, Lee S, Yu J, Bae J, Kim EJ, Bae SH, Lee JH.   +7 more
europepmc   +1 more source

DNA-encoded library screening identifies CDK2-targeting lead compounds with favorable drug-like properties for anticancer development

Liping Zhou, Yong Ju, Zhijuan Cao, Sheng Cai, Jiayuan Su, Jianzhong Lu   +5 more
openalex   +1 more source