Results 221 to 230 of about 328,812 (261)

Design of compound libraries for fragment screening

Journal of Computer-Aided Molecular Design, 2009
Approaches to the design of libraries for fragment screening are illustrated with reference to a 20 k generic fragment screening library and a 1.2 k generic NMR screening library. Tools and methods for library design that have been developed within AstraZeneca are described, including Foyfi fingerprints and the Flush program for neighborhood ...
Niklas Blomberg, David A. Cosgrove, Peter W. Kenny, Karin Kolmodin   +3 more
openaire   +2 more sources

Screening of Fluorine-Containing Compounds for Acute Toxicity

Journal of Occupational and Environmental Medicine, 1960
Abstract The maximal tolerated dose and the minimal lethal dose in mice are estimated for a series of twenty flucrine-containing organic compounds, four inorganic compounds of fluorine, and three nonfluorine-containing organic compounds.
F A, SMITH, W L, DOWNS, H C, HODGE, E A, MAYNARD   +3 more
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Strategic Pooling of Compounds for High-Throughput Screening

Journal of Chemical Information and Computer Sciences, 1999
Bringing new medicines to the market depends on the rapid discovery of new and effective drugs, often initiated through the biological testing of many thousands of compounds in high-throughput screening (HTS). Mixing compounds together into pools for screening is one way to accelerate this process and reduce costs.
Mike Hann, Brian Hudson, Xiao Lewell, Rob Lifely, Luke Miller, Nigel Ramsden   +5 more
openaire   +2 more sources

Screening of toxic compounds in tissue culture

Toxicology, 1980
To screen toxicity of chemicals most often easily manageable cultures of less differentiated cells have been used. This work includes 3 fields: (i) Screening of chemicals and fermentation broths for their cytoinhibitory effect, to predict antineoplastic activity.
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A Method for Screening of Volatile Antimicrobial Compounds

Bulletin of Environmental Contamination and Toxicology, 2011
Presently available methods for determining antimicrobial activity include broth dilution and disc diffusion. However, these methods can not be employed for study of vapor phase antimicrobial activity. The present study describes a new method and a new apparatus for determination of vapor phase antimicrobial activity of volatile substances against ...
openaire   +2 more sources

ELECTROSTATIC SCREENING IN FULLERENE COMPOUNDS

Modern Physics Letters B, 1994
We study the Coulomb interactions in fullerene compounds within a continuum formalism. The model gives rise to a renormalizable field theory, which has many similarities to standard quantum electrodynamics. The effective electric charge at low energies is reduced by screening processes.
J. GONZÁLEZ, F. GUINEA, M.A.H. VOZMEDIANO   +2 more
openaire   +1 more source

Screening for Anti-proteolytic Compounds

2009
Dietary protein entering the rumen is broken down in an apparently uncontrolled way, resulting in ammonia formation and subsequent loss of N in the urine. The low efficiency of nitrogen retention represents a major economic loss, causes metabolic stress in the animal, and places a burden on the environment, by way of nitrogen-rich wastes. If a means of
Ellen M. Hoffmann, Natascha Selje-Assmann, Klaus Becker, R. John Wallace, Glen A. Broderick   +4 more
openaire   +1 more source

[Screening of antiangiogenic compound].

Gan to kagaku ryoho. Cancer & chemotherapy, 2004
Cancer cells promote angiogenesis early in tumorigenesis because cancer cells require oxygen and nutrients for their survival they need to be supported by blood vessels. The angiogenic switch is driven by several proangiogenic factors, vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), basic fibroblast growth factor (bFGF) and others ...
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Compound Screening

2022
Shin Numao, Gianluca Etienne, Goran Malojcic, Enrico Schmidt, Christoph E. Dumelin   +4 more
openaire   +1 more source

Screening Microorganisms for Bioactive Compounds

2016
Novel bioactive compounds are in high demand due to the development of microbial antibiotic resistance, increase in age-related diseases, and requirements for optimized manufacturing processes. The bioactive compounds can act as specific antitumor, anti-inflammatory, and antifungal compounds as well as pharmaceuticals against metabolic diseases ...
Sonia Giubergia, Carmen Schleissner, Fernando de la Calle, Alexander Pretsch, Dagmar Pretsch, Lone Gram, Mariane Schmidt Thøgersen   +6 more
openaire   +1 more source