Results 241 to 250 of about 359,557 (359)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Tumor organoids in cancer medicine: from model systems to natural compound screening. [PDF]

Pharm Biol
Cong R, Lu C, Li X, Xu Z, Wang Y, Sun S.
europepmc   +1 more source

Development and Validation of Multi-Residue Analysis of 82 Pesticides in Grapes and Pomegranate as per the Requirements of the European Union (EU) and Codex Alimentarius Using GC-MS/MS with Compound Based Screening

, 2014
Gouri Satpathy, Yogesh Kumar Tyagi, Rajinder K. Gupta   +2 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening. [PDF]

Cells, 2020
Goričan L, Gole B, Potočnik U.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Compound Heterozygous Familial Hypercholesterolemia Detected by Cascade Screening

This report outlines the case of a 13-year-old non-Hispanic White male diagnosed with compound heterozygous Familial Hypercholesterolemia (FH) with a biallelic mutation in the LDLR gene.
Hamilton, Luke, Wilson, Don, Nagaram, Sumedha   +2 more
core  

Evaluation of Serum Supplementation on the Development of <i>Haemonchus contortus</i> Larvae In Vitro and on Compound Screening Results. [PDF]

Int J Mol Sci
Thilakarathne SS, Taki AC, Wang T, Nowell C, Chang BCH, Gasser RB.   +5 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases. [PDF]

ACS Omega
Leiva H, Caro De Silva PL, Painter R, Le VTB, Uychoco P, Figueroa Paniagua D, Endres M, Maltseva N, Joachimiak A, Kuhn ML.   +9 more
europepmc   +1 more source