Results 211 to 220 of about 329,386 (265)
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Substituted tetrazoles as multipurpose screening compounds
Molecular Diversity, 2016Tetrazoles are small functional heterocycles that are suited to serve simultaneously as aromatic platform for diversity and as functional interaction motif. Furthermore, the tetrazole ring and its deprotonated tetrazolate counterpart are metal ion complexing ligands that possess a rich variety of binding and bridging modes.
Nicole Rüger +5 more
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Kernels for Chemical Compounds in Biological Screening
2007Kernel methods are a class of algorithms for pattern analysis with a number of convenient features. This paper proposes extension of the kernel method for biological screening data including chemical compounds. Our investigation of extending kernel aims to combine properties of graphical structure and molecule descriptors.
Karol Kozak +2 more
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Compound Collection Preparation for Virtual Screening
2012Virtual screening is an established technique that has successfully been deployed in the identification of novel biologically active molecules. Whether for ligand-based or for structure-based virtual screening, a chemical collection needs to be properly processed prior to in silico evaluation.
Cristian G, Bologa, Tudor I, Oprea
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Virtual Compound Screening In Drug Discovery
Future Medicinal Chemistry, 2012Virtual screening (VS) methods are applied in both academia and drug discovery, and can be divided into ligand- and target structure-based approaches. The VS field is still evolving and is characterized by scientific heterogeneity. The value of virtual compound screening for drug discovery is often debated, in particular, given the large investments ...
Dagmar, Stumpfe +2 more
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Screening of toxic compounds in tissue culture
Toxicology, 1980To screen toxicity of chemicals most often easily manageable cultures of less differentiated cells have been used. This work includes 3 fields: (i) Screening of chemicals and fermentation broths for their cytoinhibitory effect, to predict antineoplastic activity.
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[Screening of antiangiogenic compound].
Gan to kagaku ryoho. Cancer & chemotherapy, 2004Cancer cells promote angiogenesis early in tumorigenesis because cancer cells require oxygen and nutrients for their survival they need to be supported by blood vessels. The angiogenic switch is driven by several proangiogenic factors, vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), basic fibroblast growth factor (bFGF) and others ...
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Social determinants of health and US cancer screening interventions: A systematic review
Ca-A Cancer Journal for Clinicians, 2023Ariella Korn
exaly