Results 191 to 200 of about 359,557 (359)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Highly sensitive genotyping of MTHFR C677T polymorphisms using a novel RPA-LDR-qPCR assay

Acta Biochimica et Biophysica Sinica, 2022
Si Xinxin, Gu Qinghua, Zhao Chenjie, Zhang Xiao, Xiao Tingting, Li Yu, Ying Wei, Gao Song   +7 more
doaj   +1 more source

Phytochemical Compound Screening to Identify Novel Small Molecules against Dengue Virus: A Docking and Dynamics Study. [PDF]

Molecules, 2022
Shimu MSS, Mahmud S, Tallei TE, Sami SA, Adam AA, Acharjee UK, Paul GK, Emran TB, Zaman S, Uddin MS, Saleh MA, Alshehri S, Ghoneim MM, Alruwali M, Obaidullah AJ, Jui NR, Kim J, Kim B.   +17 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability. [PDF]

Nat Cell Biol
D'Ambrosio M, White MEH, Gavriil ES, Bousset L, Birch J, Gruevska A, Pasquini E, Colucci M, Fong W, Mosole S, Valdata A, Veroutis D, Tyson K, Ranvir V, Prokosch S, Pombo J, Ardisson A, Khadayate S, Young G, Montoya A, Roumelioti G, Houghton J, Lu J, Shliaha PV, De Vita E, Vernia S, Gorgoulis VG, Gallage S, Heikenwälder M, Hall Z, Alimonti A, McNeish IA, Tate EW, Gil J.   +33 more
europepmc   +1 more source

SYNTHESIS, STRUCTURAL, AND BIOLOGICAL SCREENING OF SOME NEW ORGANOBISMUTH COMPOUNDS

, 2011
Tewari Ic, TIWARI VK, Sushma Rani
openalex   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The application of the fragment-based screening approach to RmlA protein and PA1645 structure

, 2014
P. aerguinosa is a serious human bacterial pathogen. This thesis describes attempts to use structural biology to identify new starting points for drugs against P.
Boulkeroua, Wassila Abdelli
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Protocol for high-throughput compound screening using flow cytometry in THP-1 cells. [PDF]

STAR Protoc, 2021
Spangenberg SH, Zavareh RB, Lairson LL.
europepmc   +1 more source