Results 181 to 190 of about 359,557 (359)

CRISPR/Cas12a combined with recombinase polymerase amplification for rapid and sensitive detection of Vibrio vulnificus in one tube

Acta Biochimica et Biophysica Sinica, 2023
Zhang Xue, Guo Bo, Yang Lihong, Zhao Chenjie, Wang Yue, Tang Yixin, Yang Guang, Wang Pei, Gao Song   +8 more
doaj   +1 more source

Studies on Heterocyclic Compounds : Part XXVIII. Synthesis of 1,3-diaryl-5-(N-substituted p-sulphamyl- benzeneazo) dihydro-2-thioxo-4,6 (1 H,5 H)-pyrimidinediones and Their in vitro Screening

, 1979
R. K. GAUTAM, H. C. MUTREJA, G. S. SAHARIA, H. R. SHARMA   +3 more
openalex   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Liensinine alleviates septic heart injury by targeting inflammation, oxidative stress, apoptosis, and autophagy

Acta Biochimica et Biophysica Sinica, 2023
Zhang Wei, Wang Tianling, Chen Huizhen, Fan Hui, Liu Feixue, Zhang Xiao, Yang Haitao, Li Xueqing, Dong Zibo, Dong Jingquan   +9 more
doaj   +1 more source

Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. [PDF]

Sci Rep, 2022
Mauro AN, Turgeon PJ, Gupta S, Brand-Arzamendi K, Chen H, Malone JH, Ng R, Ho K, Dubinsky M, Di Ciano-Oliveira C, Spring C, Plant P, Leong-Poi H, Marshall JC, Marsden PA, Connelly KA, Singh KK.   +16 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A context-aware deconfounding autoencoder for robust prediction of personalized clinical drug response from cell-line compound screening. [PDF]

Nat Mach Intell, 2022
He D, Liu Q, Wu Y, Xie L.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. [PDF]

Front Mol Biosci, 2022
Mrozek A, Antoshchenko T, Chen Y, Zepeda-Velázquez C, Smil D, Kumar N, Lu H, Park HW.   +7 more
europepmc   +1 more source

Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: Dataset of 2,891 compounds.

, 2020
Côme Thieulent, Christine Fortier, Hélène Munier‐Lehmann, Peggy Suzanne, Patrick Dallemagne, Stéphan Zientara, Aymeric Hans, Romain Paillot, Pierre‐Olivier Vidalain, Stéphane Pronost, Érika Hue   +10 more
openalex   +1 more source