Results 171 to 180 of about 359,557 (359)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Innovative Approaches to Early Detection of Cancer-Transforming Screening for Breast, Lung, and Hard-to-Screen Cancers

Early detection of cancer is crucial for improving patient outcomes. Traditional modalities such as mammography and low-dose computed tomography are effective but exhibit inherent limitations, including radiation exposure and accessibility challenges ...
Sharon Furman-Assaf, Shlomi Madar, Reef Einoch Amor, Eitan Friedman   +3 more
core   +1 more source

Identifying Small Molecule Compounds that Have Synergistic Effects With Cisplatin and Other Platinum Drugs Using High Throughput Matrix Screening

, 2022
Layla Al-Zubi, Dorian M. Cheff, Zina Itkin, Hui Guo, Min Shen, Matthew D. Hall   +5 more
openalex   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Screening Compounds Against Usp5 Zf-Ubd With A 19F Nmr Assay #2

, 2018
Mandeep Mann, Scott Houliston, Rachel Harding, A.M. Edwards, C.H. Arrowsmith, Matthieu Schapira   +5 more
openalex   +2 more sources

Rapid and sensitive detection of Oncorhynchus mykiss adulteration in Salmo salar by recombinase polymerase amplification combined with lateral flow strip

Acta Biochimica et Biophysica Sinica, 2022
Yang Qiankun, Liu Xia, Wang Lei, Yu Guili, Yang Haitao, Fu Hang, Li Xueqing, He Nana, Yu Hong, Dong Jingquan   +9 more
doaj   +1 more source

Fast fragment- and compound-screening pipeline at the Swiss Light Source. [PDF]

Acta Crystallogr D Struct Biol, 2022
Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, Huang CY, Meier N, Steuber J, Wang M, Fritz G, Wojdyla JA, Sharpe ME.   +12 more
europepmc   +1 more source

A Novel Bioassay System for Screening of Compounds Affecting Anthocyanin Biosynthesis Pathway in White Corn Leaf Segment [PDF]

, 2003
Jin‐Seog Kim
openalex   +1 more source

Investigation of the therapeutic role of native plant compounds against colorectal cancer based on system biology and virtual screening [PDF]

, 2023
Abbas Alibakhshi, Rahim Malekzadeh, Sayedeh Azimeh Hosseini, Hajar Yaghoobi   +3 more
openalex   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source