Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Metodologia feminista e direitos reprodutivos no Centro de Saúde Santa Rosa, Niterói (RJ)
Saúde em DebateO presente trabalho tem por objetivo examinar práticas feministas e femininas, em especial, aquelas presentes em uma pedagogia voltada para o processo de empoderamento político das mulheres, a Linha da Vida, largamente utilizada nas lutas dos anos de ...
Elaine França da Silva
doaj +1 more source
[Implementation of the Comprehensive Health Care Policy in Cundinamarca, Colombia 2021]. [PDF]
Rev Salud Publica (Bogota), 2023 Escobar-Díaz FA.
europepmc +1 more source
Analysis of a Permanent Prohibition on Implementing the Major Health Care Legislation Enacted in March 2010 [PDF]
, 2011 [Excerpt] This letter discusses many of the potential effects of a permanent ban on the use of appropriated funds to implement the health care laws and, where possible, provides information on whether those effects would increase or decrease direct ...
Elmendorf, Douglas W
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Response to Chagas disease in Brazil: strategic milestones for achieving comprehensive health care. [PDF]
Rev Soc Bras Med Trop, 2022 Ramos AN +12 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Saúde em DebateRESUMO O objetivo deste estudo foi o de analisar como o Núcleo de Apoio à Saúde da Família tem colaborado com as Equipes de Saúde da Família na sua função de coordenação assistencial.
Fabiana de Oliveira Silva Sousa +4 more
doaj +1 more source
Redesigning an Electronic Health Record in Argentina to Improve Comprehensive Health Care and Clinical Research. [PDF]
Stud Health Technol Inform, 2022 Giraldo L +6 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source