Results 81 to 90 of about 91,879 (279)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
World Music on a U.S. Stage: A Berne/TRIPs and Economic Analysis of the Fairness in Music Licensing Act [PDF]
, 2000 This article analyzes the dispute settlement proceedings pending before the World Trade Organization (WTO) concerning the Fairness in Music License Act of 1998, a new provision of the US Copyright Act that exempts many bars, restaurants, and retail ...
Helfer, Laurence R.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Protecting Intellectual Property in the Developing World: Next Stop—Thailand [PDF]
, 2006 This iBrief examines the U.S. strategy for strengthening the protection of intellectual property rights (IPRs) in Southeast Asia through the use of free trade agreements (FTAs). After briefly examining the U.S.
Arnold, Cortney M.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Drivers’ Knowledge, Attitude and Practices Towards Traffic Rules and Regulations
Journal of Road SafetyResearch frequently reports that the majority of crashes (up to 80%), are the fault of drivers. Further, the WHO reports that most fatal crashes occur in low- and middle-income countries (LMIC).
Sheer Abbas +3 more
doaj +1 more source
India Adds Compulsory Drug Licenses [PDF]
Cancer Discovery, 2013 Abstract The Indian government granted compulsory licenses for 3 cancer drugs, including breast cancer agents Herceptin (trastuzumab; Genentech) and Ixempra (ixabepilone; Bristol-Myers Squibb) and leukemia therapeutic Sprycel (dasatinib; Bristol-Myers Squibb).
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Developing Say Against AIDS [PDF]
, 2013 Lack of access to medicines is a hurdle for many countries, especially developing nations, in their fight against serious health problems. The World Trade Organization (WTO) has frequently been scrutinized regarding its impact on access to essential ...
Rydzefski, Joanna
core +1 more source
Does class attendance predict academic performance in first year psychology tutorials? [PDF]
, 2015 <p>Student absenteeism is common across universities. Learning through attending lectures and tutorials is still expected in our technological age, though there are major changes in how information in lectures and tutorials can be transmitted via ...
Alexander, Vic, Hicks, Richard E.
core +1 more source