Results 81 to 90 of about 91,439 (301)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Patent Protection and the Global Access to Essential Pharmaceuticals during Patent Infringements under TRIPS

Voices in Bioethics, 2014
Patents are negative legal rights that act as stop signs to prevent non-innovators from making, using, or selling inventions without expressed permission from inventors.
Emmanuel Kornyo
doaj   +1 more source

A Developing Say Against AIDS [PDF]

, 2013
Lack of access to medicines is a hurdle for many countries, especially developing nations, in their fight against serious health problems. The World Trade Organization (WTO) has frequently been scrutinized regarding its impact on access to essential ...
Rydzefski, Joanna
core   +1 more source

Student experiences and perceptions of compulsory research projects: a veterinary perspective [PDF]

, 2017
Background Although research underpins clinical work, many students training to be clinicians are not inherently interested in developing research skills.
Baxter Magolda, Braun, Bruner, Bruner, Bryman, Burgoyne, Cleland, Dale, Davis, Deci, Fraser, Funston, Garcia, Greenhalgh, Heath, Hunter, Husman, Ivankova, Krueger, Laidlaw, McManus, Miles, Murray, Park, Piaget, Rosol, Russell, Ryan, Sackett, Selbourne, Stubbs, Todd, Vygotsky, Weller, Wood, Wood   +35 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

World Music on a U.S. Stage: A Berne/TRIPs and Economic Analysis of the Fairness in Music Licensing Act [PDF]

, 2000
This article analyzes the dispute settlement proceedings pending before the World Trade Organization (WTO) concerning the Fairness in Music License Act of 1998, a new provision of the US Copyright Act that exempts many bars, restaurants, and retail ...
Helfer, Laurence R.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

India Adds Compulsory Drug Licenses [PDF]

Cancer Discovery, 2013
Abstract The Indian government granted compulsory licenses for 3 cancer drugs, including breast cancer agents Herceptin (trastuzumab; Genentech) and Ixempra (ixabepilone; Bristol-Myers Squibb) and leukemia therapeutic Sprycel (dasatinib; Bristol-Myers Squibb).
openaire   +1 more source

Stay Tuned: Whether Cloud-Based Service Providers Can Have Their Copyrighted Cake and Eat It Too [PDF]

, 2014
Copyright owners have the exclusive right to perform their works publicly and the ability to license their work to others who want to share that right. Subsections 106(4) and (5) of the Copyright Act govern this exclusive public performance right, but
Asaro, Amanda
core   +1 more source

Eradication of scrapie with selective breeding: are we nearly there? [PDF]

, 2010
Background: Following EU decision 2003/100/EC Member States have recently implemented sheep breeding programmes to reduce the prevalence of sheep with TSE susceptible prion genotypes.
Melchior, M.B., Windig, J.J., Hagenaars, T.H.J., Bossers, A., Davidse, A., Zijderveld, F.G., van   +5 more
core   +2 more sources