Results 101 to 110 of about 29,886 (270)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Features and transaction modes of data products in data markets
大数据, 2022 Developing the markets of data as a factor of production is the key in the efficient allocation of data factor.However, the early practices of data markets in China have revealed a series of problems, which urgently calls for a systematic review and ...
Lihua HUANG +4 more
doaj
Computational Toxicology [PDF]
Chemical Research in Toxicology, 2020 Nicole C. Kleinstreuer +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
On computable subgroups of the group of all unitriangular matrices over a ring
Қарағанды университетінің хабаршысы. Математика сериясы, 2017 The problems of existence and uniqueness of computable numberings are fundamental in theory of computably numbered groups. In connection with the development of the theory of algorithms a study of the problems of computability of important classes of ...
R.K. Tyulyubergenev
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Gödel’s Philosophical Challenge (to Turing)
Studia Semiotyczne, 2020 DOI: http://doi.org/10.26333/sts.xxxiv1.03 The incompleteness theorems constitute the mathematical core of Gödel’s philosophical challenge. They are given in their “most satisfactory form”, as Gödel saw it, when the formality of theories to which they
Wilfried Sieg
doaj
Bacteria as computers making computers [PDF]
FEMS Microbiology Reviews, 2009 Various efforts to integrate biological knowledge into networks of interactions have produced a lively microbial systems biology. Putting molecular biology and computer sciences in perspective, we review another trend in systems biology, in which recursivity and information replace the usual concepts of differential equations, feedback and feedforward ...
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source