Results 81 to 90 of about 29,886 (270)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2020 In this paper we extend the approach of M. Cavaleri to effective amenability to the class of computably enumerable groups, i.e. in particular we do not assume that groups are finitely generated.
Duda, Karol
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Presents a critical analysis of Hayek in the light of modern computability and economic computability theory.Hayek, Computability ...
Cockshott, W. Paul, Cottrell, Allin
core +1 more source
Characterization theorem for the conditionally computable real functions
, 2017 The class of uniformly computable real functions with respect to a small subrecursive class of operators computes the elementary functions of calculus, restricted to compact subsets of their domains.
Georgiev, Ivan
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Computing with Functionals—Computability Theory or Computer Science?
Bulletin of Symbolic Logic, 2006 AbstractWe review some of the history of the computability theory of functionals of higher types, and we will demonstrate how contributions from logic and theoretical computer science have shaped this still active subject.
openaire +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Is Every Cognitive Phenomenon Computable?
MathematicsAccording to the Church–Turing thesis, the limit of what is computable is bounded by Turing machines. Following from this, given that general computable functions formally describe the notion of recursive mechanisms, it is sometimes argued that every ...
Fernando Rodriguez-Vergara +1 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source