Results 81 to 90 of about 3,053,426 (341)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
HİLBERT’İN BİÇİMSELLEŞTİRME PROGRAMININ FELSEFESİ
Felsefe Dünyası, 2014 Bu yazıda, Hilbert’in biçimselleştirme programına kadar giden matematikfelsefesindeki önemli krizlerden bahsedilmiştir. Hilbert’in programınıngerçekleşemeyeceğini gösteren Gödel’in eksiklik teoremi gibi programınsonuçları ve nedenleri tartışılmıştır ...
Ahmet Çevik
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Basics of Intensionalized Data: Presets, Sets, and Nominats [PDF]
Computer Science Journal of Moldova, 2012 In the paper we consider intensional aspects of the notion of data. We advocate an idea that traditional set-theoretic platform should be enhanced with new data structures having explicit intensional component.
Mykola Nikitchenko, Alexey Chentsov
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Computer science, computer, computational complexity
Chebyshevskii sbornik, 2021 Vladimir Nikolaevich Chubarikov +3 more
openaire +2 more sources
Quantum Computation in Computational Geometry
Interdisciplinary Information Sciences, 2002 Summary: We discuss applications of quantum computation to geometric data processing. These applications include problems on convex hulls, minimum enclosing balls, linear programming, and intersection problems. Technically, we apply the well-known algorithm of \textit{L. K. Grover} [Proc. 28th annual ACM symposium 1996, 212--219 (1996; Zbl 0922.68044)]
Sadakane, Kunihiko +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Weighted Least Squares Regression with the Best Robustness and High Computability
AxiomsA novel regression method is introduced and studied. The procedure weights squared residuals based on their magnitude. Unlike the classic least squares which treats every squared residual as equally important, the new procedure exponentially down-weights
Yijun Zuo, Hanwen Zuo
doaj +1 more source
Features and transaction modes of data products in data markets
大数据, 2022 Developing the markets of data as a factor of production is the key in the efficient allocation of data factor.However, the early practices of data markets in China have revealed a series of problems, which urgently calls for a systematic review and ...
Lihua HUANG +4 more
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