Results 91 to 100 of about 1,427,211 (329)

Functional impact of multi-omic interactions in lung cancer

open access: yesFrontiers in Genetics
Lung tumors are a leading cause of cancer-related death worldwide. Lung cancers are highly heterogeneous on their phenotypes, both at the cellular and molecular levels.
Miguel Ángel Díaz-Campos   +5 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

On the Complexity of Target Set Selection in Simple Geometric Networks [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science
We study the following model of disease spread in a social network. At first, all individuals are either infected or healthy. Next, in discrete rounds, the disease spreads in the network from infected to healthy individuals such that a healthy individual
Michal Dvořák   +2 more
doaj   +1 more source

Computational Complexity of the Interleaving Distance

open access: yes, 2018
The interleaving distance is arguably the most prominent distance measure in topological data analysis. In this paper, we provide bounds on the computational complexity of determining the interleaving distance in several settings.
Bjerkevik, Håvard Bakke   +1 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Computer science, computer, computational complexity

open access: yesChebyshevskii sbornik, 2021
Vladimir Nikolaevich Chubarikov   +3 more
openaire   +2 more sources

Master Regulators of Signaling Pathways: An Application to the Analysis of Gene Regulation in Breast Cancer

open access: yesFrontiers in Genetics, 2019
Analysis of gene regulatory networks allows the identification of master transcriptional factors that control specific groups of genes. In this work, we inferred a gene regulatory network from a large dataset of breast cancer samples to identify the ...
Diana Tapia-Carrillo   +5 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

The computational complexity of convex bodies

open access: yes, 2006
We discuss how well a given convex body B in a real d-dimensional vector space V can be approximated by a set X for which the membership question: ``given an x in V, does x belong to X?'' can be answered efficiently (in time polynomial in d).
Barvinok, Alexander, Veomett, Ellen
core   +1 more source

The Computational Complexity of the Traveling Salesman Problem [PDF]

open access: yes, 2011
In this note, we show that the Traveling Salesman Problem cannot be solved in polynomial-time on a classical computer.Comment: 1 page, made a minor ...
Feinstein, Craig Alan
core   +2 more sources

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