Results 61 to 70 of about 1,437,104 (331)
Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status
Frontiers in Cardiovascular MedicineCardiovascular diseases stand as a prominent global cause of mortality, their intricate origins often entwined with comorbidities and multimorbid conditions.
Héctor A. Cruz-Ávila +5 more
doaj +1 more source
On sample complexity for computational pattern recognition
, 2005 In statistical setting of the pattern recognition problem the number of examples required to approximate an unknown labelling function is linear in the VC dimension of the target learning class.
Ryabko, Daniil
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Optical Computing and Computational Complexity
, 2006 This work concerns the computational complexity of a model of computation that is inspired by optical computers. The model is called the continuous space machine and operates in discrete timesteps over a number of two-dimensional images of fixed size and arbitrary spatial resolution.
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
MathematicsWe investigate a nonlinear integral equation derived through moment approximation from the individual-based representation of spatial logistic dynamics. The equation describes how the densities of pairs of individuals represented by points in continuous ...
Mikhail Nikolaev +2 more
doaj +1 more source
Complexity Theory, Game Theory, and Economics: The Barbados Lectures
, 2020 This document collects the lecture notes from my mini-course "Complexity Theory, Game Theory, and Economics," taught at the Bellairs Research Institute of McGill University, Holetown, Barbados, February 19--23, 2017, as the 29th McGill Invitational ...
Roughgarden, Tim
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Epistemic virtues, metavirtues, and computational complexity [PDF]
, 2003 I argue that considerations about computational complexity show that all finite agents need characteristics like those that have been called epistemic virtues.
Morton, Professor Adam
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