Results 61 to 70 of about 17,712,238 (346)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computational materials design [PDF]

Nature Materials, 2021
Stephen, Shevlin, Bruno, Castro, Xin, Li
openaire   +2 more sources

Computational design of a modular protein sense-response system

Science, 2019
Sense and respond Many signaling pathways start with cellular proteins sensing and responding to small molecules. Despite advances in protein design, creating a protein-based sense-and-respond system remains challenging. Glasgow et al.
A. Glasgow, Yao-ming Huang, D. J. Mandell, M. Thompson, Ryan S. Ritterson, Amanda L. Loshbaugh, J. Pellegrino, C. Krivacic, Roland A. Pache, Kyle A. Barlow, Noah Ollikainen, Deborah Jeon, M. Kelly, J. Fraser, T. Kortemme   +14 more
semanticscholar   +1 more source

Computational support for early stage architectural design [PDF]

, 2007
The concepts underlying 'scenario-based' design are introduced. From the analysis of a number of struc-tured interviews with practicing designers, key design scenarios are identified.
Bridges, A.H.
core  

Analysis and Optimization of Aperture Design in Computational Imaging

, 2017
There is growing interest in the use of coded aperture imaging systems for a variety of applications. Using an analysis framework based on mutual information, we examine the fundamental limits of such systems---and the associated optimum aperture coding--
Thrampoulidis, Christos, Wornell, Gregory, Yedidia, Adam   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Challenges and Opportunities in Scaling up Architectural Applications of Mycelium-Based Materials with Digital Fabrication

Biomimetics, 2022
In an increasing effort to address the environmental challenges caused by the currently linear economic paradigm of “produce, use, and discard”, the construction industry has been shifting towards a more circular model.
Selina Bitting, Tiziano Derme, Juney Lee, Tom Van Mele, Benjamin Dillenburger, Philippe Block   +5 more
doaj   +1 more source

Parallel Computational Protein Design [PDF]

, 2016
Computational structure-based protein design (CSPD) is an important problem in computational biology, which aims to design or improve a prescribed protein function based on a protein structure template. It provides a practical tool for real-world protein engineering applications.
Yichao, Zhou, Bruce R, Donald, Jianyang, Zeng   +2 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An Integrated Workflow for Designing and Fabricating Multi-Functional Building Components through Additive Manufacturing with Clay

Buildings, 2023
This article presents a project that explores the potential of Additive Manufacturing (AM) for designing and fabricating multi-functional building components for improved climate performance.
Ammar Taher, Serdar Aşut, Willem van der Spoel   +2 more
doaj   +1 more source