Results 31 to 40 of about 75,962 (250)

Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): uncertainty quantification of geometric rupture risk parameters

BioMedical Engineering OnLine, 2019
Background Geometric parameters have been proposed for prediction of cerebral aneurysm rupture risk. Predicting the rupture risk for incidentally detected unruptured aneurysms could help clinicians in their treatment decision.
Leonid Goubergrits, Florian Hellmeier, Jan Bruening, Andreas Spuler, Hans-Christian Hege, Samuel Voss, Gábor Janiga, Sylvia Saalfeld, Oliver Beuing, Philipp Berg   +9 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Review on the Mixing Quality of Static Mixers

ChemEngineering
Static mixers are widely used devices for efficient fluid mixing, homogenization, and enhancement of heat transfer, with applications ranging from chemical processing and pharmaceutical manufacturing to wastewater treatment.
Lukas von Damnitz, Denis Anders
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Robotic Pectoral Fin Thrust Vectoring Using Weighted Gait Combinations

Applied Bionics and Biomechanics, 2012
A method was devised to vector propulsion of a robotic pectoral fin by means of actively controlling fin surface curvature. Separate flapping fin gaits were designed to maximize thrust for each of three different thrust vectors: forward, reverse, and ...
John S. Palmisano, Jason D. Geder, Ravi Ramamurti, William C. Sandberg, Banahalli Ratna   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

CFD Simulation of UV Disinfection Reactor for Applesauce with a Low UV Absorption Coefficient

Journal of Chemical and Petroleum Engineering, 2014
In this study, a Computational Fluid Dynamics (CFD) model was developed to evaluate ultraviolet disinfection applesauce reactor. To simulate UV reactors, three sets of equations, including hydrodynamics, radiation and species mass conservation were ...
Seyed Hassan Hashemabadi, Farkhondeh Ghaderzadeh, Fariborz Taghipour   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect of louver baffles installation on hydrodynamics of bubbling fluidization in biomass gasifier

Scientific Reports, 2022
Biomass gasification by a bubbling bed gasifier has been a promising process to produce fuels from biomass. However, the performance is limited by gas aggregation in the gasifier.
Kiattikhoon Phuakpunk, Benjapon Chalermsinsuwan, Suttichai Assabumrungrat   +2 more
doaj   +1 more source