Results 41 to 50 of about 75,414 (250)

MPAS‐Ocean Simulation Quality for Variable‐Resolution North American Coastal Meshes

Journal of Advances in Modeling Earth Systems, 2020
Climate model components utilizing unstructured meshes enable variable resolution, regionally enhanced simulations within global domains. Here we investigate the relationship between mesh quality and simulation statistics using the JIGSAW unstructured ...
Kristin E. Hoch, Mark R. Petersen, Steven R. Brus, Darren Engwirda, Andrew F. Roberts, Kevin L. Rosa, Phillip J. Wolfram   +6 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Effect of secondary swirl in supersonic gas and plasma flows in the self-vacuuming vortex tube

MATEC Web of Conferences, 2018
This article presents the results of simulation for a special type of vortex tubes – self-vacuuming vortex tube (SVT), for which extreme values of temperature separation and pressure drop are realized.
Volov Vyacheslav, Lyaskin Anton
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Comparative numerical studies of the mechanical efficiency of sandwich-panels with different non-/auxetic prismatic and lattice cores subjected to ballistic loading

Forces in Mechanics
Civil as well as military facilities, vehicles and applications must increasingly meet higher safety standards to ensure the highest possible protection against extraordinary stresses such as ballistic and/or air-blast loading.
Marcel Walkowiak, Denis Anders, Ulf Reinicke   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Influence of Viscosity on the Shape of an Air Taylor Bubble in a Stagnant Liquid Under Turbulent Condition in Falling Film

International Journal of Applied Mechanics and Engineering, 2019
This work aims to find the influence of the liquid viscosity on the shape of an air Taylor bubble, rising up in a pipe column which contains the liquid under conditions that the liquid is stagnant and the Froude number is approximately equal to 0.35 ...
B. Lertnuwat
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Numerical Simulation and Analysis of the Manufacturing Process of Pre-Bulged Rupture Discs

Applied Sciences
Rupture discs, also known as bursting discs, are indispensable components in fluid-operated systems providing effective protection against hazardous over-pressure or partial vacuum.
Benjamin Treude, Denis Anders, Kerstin Weinberg   +2 more
doaj   +1 more source