Results 41 to 50 of about 492,142 (334)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Review on the Mixing Quality of Static Mixers

ChemEngineering
Static mixers are widely used devices for efficient fluid mixing, homogenization, and enhancement of heat transfer, with applications ranging from chemical processing and pharmaceutical manufacturing to wastewater treatment.
Lukas von Damnitz, Denis Anders
doaj   +1 more source

Capturing the Knudsen layer in continuum-fluid models of non-equilibrium gas flows [PDF]

, 2005
In hypersonic aerodynamics and microflow device design, the momentum and energy fluxes to solid surfaces are often of critical importance. However, these depend on the characteristics of the Knudsen layer - the region of local non-equilibrium existing up
Gallis, Michael A., Lockerby, Duncan A., Reese, Jason M.   +2 more
core   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

MPAS‐Ocean Simulation Quality for Variable‐Resolution North American Coastal Meshes

Journal of Advances in Modeling Earth Systems, 2020
Climate model components utilizing unstructured meshes enable variable resolution, regionally enhanced simulations within global domains. Here we investigate the relationship between mesh quality and simulation statistics using the JIGSAW unstructured ...
Kristin E. Hoch, Mark R. Petersen, Steven R. Brus, Darren Engwirda, Andrew F. Roberts, Kevin L. Rosa, Phillip J. Wolfram   +6 more
doaj   +1 more source

Helicopter Fuselage Drag ─ Combined Computational Fluid Dynamics and Experimental Studies [PDF]

, 2015
In this paper, wind tunnel experiments are combined with Computational Fluid Dynamics (CFD) aiming to analyze the aerodynamics of realistic fuselage con¦gurations.
Barakos, G., Batrakov, A., Kusyumov, A., Mikhailov, S., Pakhov, V., Sungatullin, A., Valeev, M., Zherekhov, V.   +7 more
core   +2 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Distributed computational fluid dynamics [PDF]

, 2003
Computational fluid dynamics simulations of relevance to jet-engine design, for instance, are extremely computationally demanding and the use of large-scale distributed computing will allow the solution of problems that cannot be tackled using current ...
,, Cant, RS, Hayes, M, Jenkins, KW, Yang, X   +4 more
core   +1 more source