Results 61 to 70 of about 724,157 (279)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Single-shot super-resolved fringe projection profilometry (SSSR-FPP): 100,000 frames-per-second 3D imaging with deep learning

Light: Science & Applications
To reveal the fundamental aspects hidden behind a variety of transient events in mechanics, physics, and biology, the highly desired ability to acquire three-dimensional (3D) images with ultrafast temporal resolution has been long sought.
Bowen Wang, Wenwu Chen, Jiaming Qian, Shijie Feng, Qian Chen, Chao Zuo   +5 more
doaj   +1 more source

Autofocusing Algorithm for Pixel-Super-Resolved Lensfree On-Chip Microscopy

Frontiers in Physics, 2021
In recent years, lensfree on-chip microscopy has developed into a promising and powerful computational optical microscopy technique that allows for wide-field, high-throughput microscopic imaging without using any lenses.
Yumin Wu, Yumin Wu, Yumin Wu, Yumin Wu, Linpeng Lu, Linpeng Lu, Linpeng Lu, Linpeng Lu, Jialin Zhang, Jialin Zhang, Jialin Zhang, Jialin Zhang, Zhuoshi Li, Zhuoshi Li, Zhuoshi Li, Zhuoshi Li, Chao Zuo, Chao Zuo, Chao Zuo, Chao Zuo   +19 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Principal component analysis for three-dimensional structured illumination microscopy (PCA-3DSIM)

Light: Science & Applications
Three-dimensional structured illumination microscopy (3DSIM) is an essential super-resolution imaging technique for visualizing volumetric subcellular structures at the nanoscale, capable of doubling both lateral and axial resolution beyond the ...
Jiaming Qian, Weiyi Xia, Yuxia Huang, Jing Feng, Qian Chen, Chao Zuo   +5 more
doaj   +1 more source

Impact of valve morphology, hypertension and age on aortic wall properties in patients with coarctation: a two-centre cross-sectional study

BMJ Open, 2020
Objective We aimed to investigate the combined effects of arterial hypertension, bicuspid aortic valve disease (BAVD) and age on the distensibility of the ascending and descending aortas in patients with aortic coarctation.Design Cross-sectional study ...
Felix Berger, Stephan Schubert, Niky Ghorbani, Vivek Muthurangu, Abbas Khushnood, Leonid Goubergrits, Sarah Nordmeyer, Joao Filipe Fernandes, Chong-Bin Lee, Kilian Runte, Sophie Roth, Sebastian Kelle, Titus Kuehne, Marcus Kelm   +13 more
doaj   +1 more source

Analysis and Optimization of Aperture Design in Computational Imaging

, 2017
There is growing interest in the use of coded aperture imaging systems for a variety of applications. Using an analysis framework based on mutual information, we examine the fundamental limits of such systems---and the associated optimum aperture coding--
Thrampoulidis, Christos, Wornell, Gregory, Yedidia, Adam   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Computational ghost imaging using deep learning

, 2017
Computational ghost imaging (CGI) is a single-pixel imaging technique that exploits the correlation between known random patterns and the measured intensity of light transmitted (or reflected) by an object.
Endo, Yutaka, Hasegawa, Satoki, Hirayama, Ryuji, Ito, Tomoyoshi, Kakue, Takashi, Nagahama, Yuki, Nishitsuji, Takashi, Sano, Marie, Shimobaba, Tomoyoshi, Shiraki, Atsushi, Takahashi, Takayuki   +10 more
core   +1 more source