Results 61 to 70 of about 271,448 (263)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multimodal adaptive temporal phase unwrapping using deep learning and physical priors

APL Photonics
In optical 3D measurement, temporal phase unwrapping (TPU) is widely employed in fringe projection and interferometry, as it is crucial for resolving wrapped phase ambiguities and obtaining absolute phase distributions.
Yiheng Liu, Xinsheng Li, Ziheng Jin, Wenwu Chen, Edmund Y. Lam, Shijie Feng, Qian Chen, Chao Zuo   +7 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Deep-learning-enabled temporally super-resolved multiplexed fringe projection profilometry: high-speed kHz 3D imaging with low-speed camera

PhotoniX
Recent advances in imaging sensors and digital light projection technology have facilitated rapid progress in 3D optical sensing, enabling 3D surfaces of complex-shaped objects to be captured with high resolution and accuracy.
Wenwu Chen, Shijie Feng, Wei Yin, Yixuan Li, Jiaming Qian, Qian Chen, Chao Zuo   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Pixel-super-resolved lens-free quantitative phase microscopy with partially coherent illumination

npj Nanophotonics
Lens-free on-chip microscopy (LFOCM) has been widely utilized in digital pathology, drug screening, point-of-care testing (POCT), and quantitative phase imaging (QPI) due to its high throughput imaging capability and compactness.
Yang Chen, Xuejuan Wu, Linpeng Lu, Jiasong Sun, Runnan Zhang, Wenhui Lin, Yufan Chen, Maciej Trusiak, Peng Gao, Chao Zuo   +9 more
doaj   +1 more source

Building Extraction From High-Resolution Multispectral and SAR Images Using a Boundary-Link Multimodal Fusion Network

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Automatically extracting buildings with high precision from remote sensing images is crucial for various applications. Due to their distinct imaging modalities and complementary characteristics, optical and synthetic aperture radar (SAR) images serve as ...
Zhe Zhao, Boya Zhao, Yuanfeng Wu, Zutian He, Lianru Gao   +4 more
doaj   +1 more source

Computational Imaging for Enhanced Computer Vision

CoRR
International Journal of Engineering Research & Technology ...
Humera Shaikh, Jashanpreet Kaur
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source