Results 91 to 100 of about 2,977,079 (288)

Computational methods for ideal compressible flow [PDF]

Conservative dissipative difference schemes, the recognition and representation of discontinuities, and multidimensional methods are ...
Vanleer, B.
core   +1 more source

A Stochastic Multi-scale Approach for Numerical Modeling of Complex Materials - Application to Uniaxial Cyclic Response of Concrete

, 2016
In complex materials, numerous intertwined phenomena underlie the overall response at macroscale. These phenomena can pertain to different engineering fields (mechanical , chemical, electrical), occur at different scales, can appear as uncertain, and are
Adnan Ibrahimbegovic, Adnan Ibrahimbegović, Ana Paula Moreno Trigo, André Zaoui, C. Miehe, D.C. Charmpis, Damijan Markovic, Dimitris Savvas, F. Ragueneau, Frédéric Feyel, George Deodatis, George Deodatis, J. Lubliner, M Gioffrè, M.D. Shields, Martin Ostoja-Starzewski, Masanobu Shinozuka, P. Germain, P. Ladevèze, Paolo Bocchini, Pierre Jehel, Pierre Jehel, R. Cottereau, R. Popescu, Sia Nemat-Nasser, Vissarion Papadopoulos   +25 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Female vs. Male Ampelmännchen-Gender-Specific Reaction Times to Male and Female Traffic Light Figures

Frontiers in Psychology, 2017
Traffic signs are important visual guiding signals for the safe navigation through complex road traffic. Interestingly, there is little variation in the traffic signs for cars around the world.
Farid I. Kandil, Farid I. Kandil, Bettina Olk, Bettina Olk, Claus C. Hilgetag, Claus C. Hilgetag   +5 more
doaj   +1 more source

Adaptive computational methods for aerothermal heating analysis [PDF]

The development of adaptive gridding techniques for finite-element analysis of fluid dynamics equations is described. The developmental work was done with the Euler equations with concentration on shock and inviscid flow field capturing.
Oden, J. Tinsley, Price, John M.
core   +1 more source

Computational morphogenesis of free form shells: Filter methods to create alternative solutions [PDF]

, 2009
p. 536-547Actual trends in numerical shape optimal design of structures deal with handling of very large dimensions of design space. The goal is to allowing as much design freedom as possible while considerably reducing the modelling effort.
BLETZINGER, Kai-Uwe, FIRI, Matthias, LINHARD, Johannes, WÜCHNER, Roland   +3 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Structural degradation assessment of a preheater tower in a cement plant in Peru

Case Studies in Construction Materials
This article examines the structural behavior of a paradigmatic case in the cement industry: an existing reinforced concrete (RC) Preheater Tower (PT).
Paula Barboza, Enzo Martinelli, Guillermo Etse   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source