Results 41 to 50 of about 161,334 (315)
Computational Modeling, Formal Analysis, and Tools for Systems Biology. [PDF]
PLoS Computational Biology, 2016 As the amount of biological data in the public domain grows, so does the range of modeling and analysis techniques employed in systems biology. In recent years, a number of theoretical computer science developments have enabled modeling methodology to ...
Ezio Bartocci, Pietro Lió
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Quantum-Field-Theoretic Simulation Platform for Observing the Fate of the False Vacuum
PRX Quantum, 2021 We design and implement a quantum annealing simulation platform to observe and study dynamical processes in quantum field theory (QFT). Our approach encodes the field theory as an Ising model, which is then solved by a quantum annealer.
Steven Abel, Michael Spannowsky
doaj +1 more source
Bulletin of Taras Shevchenko National University of Kyiv. Series: Physics and Mathematics, 2021 A complete system of functions based on non-orthogonal sinuses and cosine was constructed. It has been proven that the continuous function can be approximated by a finite number of non-orthogonal functions in such a way that this amount does not enter the selected function of the non-orthogonal base. The numerical experiment confirmed the high accuracy
openaire +2 more sources
Variational Time Integrators in Computational Solid Mechanics [PDF]
, 2003 This thesis develops the theory and implementation of variational integrators for computational solid mechanics problems, and to some extent, for fluid mechanics problems as well.
Lew, Adrián José
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
, 2003 Whilst there has been an explosion of interest in multi-agent systems, there are still many problems that may have a potentially deleterious impact on the progress of the area. These prob- lems have arisen primarily through the lack of a common structure
Luck, Michael +4 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Computational characterization of dimerization and ligand binding in biological systems [PDF]
, 2013 The self-association of proteins to form dimers or higher-order oligomers is a very common phenomenon in biology. Protein dimerization or oligomerization acts as a control tool for the execution of functions in many biological systems. Three systems were
Zhang, Lixian
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source