Results 61 to 70 of about 147,636 (266)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
High Performance Numerical Computing for High Energy Physics: A New Challenge for Big Data Science
Advances in High Energy Physics, 2014 Modern physics is based on both theoretical analysis and experimental validation. Complex scenarios like subatomic dimensions, high energy, and lower absolute temperature are frontiers for many theoretical models. Simulation with stable numerical methods
Florin Pop
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Известия высших учебных заведений: Проблемы энергетикиThe RELEVANCE of this study is to develop a computer model for assessing and predicting the reliability parameters of power supply system circuits for facilities with 10/0.4 kV transformer substations.METHODS: Reliability theory and probability theory ...
Renata M. Petrova, Elena I. Gracheva
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Formal Methods Unifying Computing Science and Systems Theory
Journal of Systemics, Cybernetics and Informatics, 2004 Computing Science and Systems Theory can gain much from unified mathematical models and methodology, in particular formal reasoning ("letting the symbols do the work"). This is achieved by a wide-spectrum formalism. The language uses just four constructs, yet suffices to synthesize familiar notations (minus the defects) as well as new ones. It supports
openaire +4 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2018 The rapid development of omics technology provides an opportunity for fulfilling the understanding of the synergistic mechanism of combination therapy. However, a systems theory to analyze synergy remains an ongoing challenge.
Peng-lu Wei, Hao Gu, Jun Liu, Zhong Wang
doaj +1 more source