Results 71 to 80 of about 161,334 (315)

New computational paradigms in solving fault detection and isolation problems

, 2012
Several fault detection and isolation problems are formulated for linear time-invariant systems with additive faults and general existence conditions of their solutions are given.
Varga, Andreas
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Practical Algorithm for Multiple-Phase Control Systems in Agricultural and Natural Resource Economics

Journal of Agricultural and Resource Economics, 2009
Many important problems in agricultural and natural resource economics concern an intertemporal choice between alternate dynamic systems. This significance has motivated a theoretical literature generalizing the necessary conditions of Optimal Control ...
Graeme J. Doole
doaj   +1 more source

Computational Mechanism Design: A Call to Arms

, 2003
Game theory has developed powerful tools for analyzing decision making in systems with multiple autonomous actors. These tools, when tailored to computational settings, provide a foundation for building multiagent software systems.
Jennings, N. R., Dash, Rajdeep K, Parkes, David C, Jennings, NR   +3 more
core  

Meshless methods: theory and application in 3D fracture modelling with level sets [PDF]

, 2010
Accurate analysis of fracture is of vital importance yet methods for effetive 3D calculations are currently unsatisfactory. In this thesis, novel numerical techniques are developed which solve many of these problems. This thesis consists two major parts:
ZHUANG, XIAOYING
core  

An overview of the proper generalized decomposition with applications in computational rheology [PDF]

, 2011
We review the foundations and applications of the proper generalized decomposition (PGD), a powerful model reduction technique that computes a priori by means of successive enrichment a separated representation of the unknown field.
Leygue, A., CHINESTA SORIA, Francisco, Chinesta, Francisco, A. Ammar, LEYGUE, Adrien, F. Chinesta, KEUNINGS, Roland, Ammar, A., R. Keunings, AMMAR, Amine, Chinesta, F., A. Leygue   +11 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Computational Entropy Modeling for Sustainable Energy Systems: A Review of Numerical Techniques, Optimization Methods, and Emerging Applications

Energies
Thermodynamic entropy generation quantifies irreversibility in energy conversion processes, providing rigorous thermodynamic foundations for optimizing efficiency and sustainability in thermal and energy systems. This critical review synthesizes advances
Łukasz Łach
doaj   +1 more source

Agent-Based Computational Economics: A Constructive Approach to Economic Theory [PDF]

This chapter explores the potential advantages and disadvantages of Agent-based Computational Economics (ACE) for the study of economic systems. General points are concretely illustrated using an ACE model of a two-sector decentralized market economy ...
Tesfatsion, Leigh
core